Semantic memory functional mri and cognitive function after exercise intervention in mild cognitive impairment

J. Carson Smith, Kristy A. Nielson, Piero Antuono, Jeri Annette Lyons, Ryan J. Hanson, Alissa M. Butts, Nathan Hantke, Matthew D. Verber

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Mild cognitive impairment (MCI) is associated with early memory loss, Alzheimer's disease (AD) neuropathology, inefficient or ineffective neural processing, and increased risk for AD. Unfortunately, treatments aimed at improving clinical symptoms or markers of brain function generally have been of limited value. Physical exercise is often recommended for people diagnosed with MCI, primarily because of its widely reported cognitive benefits in healthy older adults. However, it is unknown if exercise actually benefits brain function during memory retrieval in MCI. Here, we examined the effects of exercise training on semantic memory activation during functional magnetic resonance imaging (fMRI). Seventeen MCI participants and 18 cognitively intact controls, similar in sex, age, education, genetic risk, and medication use, volunteered for a 12-week exercise intervention consisting of supervised treadmill walking at a moderate intensity. Both MCI and control participants significantly increased their cardiorespiratory fitness by approximately 10% on a treadmill exercise test. Before and after the exercise intervention, participants completed an fMRI famous name discrimination task and a neuropsychological battery, Performance on Trial 1 of a list-learning task significantly improved in the MCI participants. Eleven brain regions activated during the semantic memory task showed a significant decrease in activation intensity following the intervention that was similar between groups (p-values ranged 0.048 to 0.0001). These findings suggest exercise may improve neural efficiency during semantic memory retrieval in MCI and cognitively intact older adults, and may lead to improvement in cognitive function. Clinical trials are needed to determine if exercise is effective to delay conversion to AD.

Original languageEnglish (US)
Pages (from-to)197-215
Number of pages19
JournalJournal of Alzheimer's Disease
Volume37
Issue number1
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

Fingerprint

Semantics
Cognition
Alzheimer Disease
Exercise Test
Brain
Magnetic Resonance Imaging
Exercise
Sex Education
Memory Disorders
Cognitive Dysfunction
Walking
Names
Clinical Trials
Learning
Efficiency

Keywords

  • Alzheimer's disease
  • dementia
  • exercise
  • magnetic resonance imaging
  • memory
  • non-pharmacologic treatment
  • physical activity
  • physical fitness

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Carson Smith, J., Nielson, K. A., Antuono, P., Lyons, J. A., Hanson, R. J., Butts, A. M., ... Verber, M. D. (2013). Semantic memory functional mri and cognitive function after exercise intervention in mild cognitive impairment. Journal of Alzheimer's Disease, 37(1), 197-215. https://doi.org/10.3233/JAD-130467

Semantic memory functional mri and cognitive function after exercise intervention in mild cognitive impairment. / Carson Smith, J.; Nielson, Kristy A.; Antuono, Piero; Lyons, Jeri Annette; Hanson, Ryan J.; Butts, Alissa M.; Hantke, Nathan; Verber, Matthew D.

In: Journal of Alzheimer's Disease, Vol. 37, No. 1, 01.01.2013, p. 197-215.

Research output: Contribution to journalArticle

Carson Smith, J, Nielson, KA, Antuono, P, Lyons, JA, Hanson, RJ, Butts, AM, Hantke, N & Verber, MD 2013, 'Semantic memory functional mri and cognitive function after exercise intervention in mild cognitive impairment', Journal of Alzheimer's Disease, vol. 37, no. 1, pp. 197-215. https://doi.org/10.3233/JAD-130467
Carson Smith, J. ; Nielson, Kristy A. ; Antuono, Piero ; Lyons, Jeri Annette ; Hanson, Ryan J. ; Butts, Alissa M. ; Hantke, Nathan ; Verber, Matthew D. / Semantic memory functional mri and cognitive function after exercise intervention in mild cognitive impairment. In: Journal of Alzheimer's Disease. 2013 ; Vol. 37, No. 1. pp. 197-215.
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