Self-reported exposures and their association with unexplained illness in a population-based case-control study of Gulf War Veterans

Peter S. Spencer, Linda A. McCauley, Jodi A. Lapidus, Michael Lasarev, Sandra K. Joos, Daniel Storzbach

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Many factors have been considered as possible causes of the unexplained illness reported by veterans of the Gulf War (GW). In this study, we report an analysis of risk factors and unexplained illness in a population-based sample of GW veterans who underwent clinical evaluation. Multiple risk factors were compared in 241 veterans who met criteria for unexplained illness and 113 healthy controls. Results suggest that GW unexplained illness is most highly associated with combat conditions, heat stress, and having sought medical attention during the GW. When controlling for multiple simultaneous exposures during the GW, interactions around pyridostigmine bromide, insecticides and repellents, and stress were not significant. These results indicate that most unexplained illness in GW veterans cannot be explained by neurotoxic effects of exposures to chemicals that inhibit cholinesterase activity.

Original languageEnglish (US)
Pages (from-to)1041-1056
Number of pages16
JournalJournal of occupational and environmental medicine
Volume43
Issue number12
DOIs
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Fingerprint Dive into the research topics of 'Self-reported exposures and their association with unexplained illness in a population-based case-control study of Gulf War Veterans'. Together they form a unique fingerprint.

  • Cite this