Self-administration enhances excitatory synaptic transmission in the bed nucleus of the stria terminalis

Eric C. Dumont, Gregory Mark, Sarah Mader, John Williams

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Understanding the neurobiology of motivation might help in reducing compulsive behaviors such as drug addiction or eating disorders. This study shows that excitatory synaptic transmission was enhanced in the bed nucleus of the stria terminalis of rats that performed an operant task to obtain cocaine or palatable food. There was no effect when cocaine or food was delivered passively, suggesting that synaptic plasticity in this area is involved in reward-seeking behaviors.

Original languageEnglish (US)
Pages (from-to)413-414
Number of pages2
JournalNature Neuroscience
Volume8
Issue number4
DOIs
StatePublished - Apr 2005

Fingerprint

Septal Nuclei
Self Administration
Cocaine
Synaptic Transmission
Compulsive Behavior
Food
Neuronal Plasticity
Neurobiology
Reward
Substance-Related Disorders
Motivation
Feeding and Eating Disorders

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Self-administration enhances excitatory synaptic transmission in the bed nucleus of the stria terminalis. / Dumont, Eric C.; Mark, Gregory; Mader, Sarah; Williams, John.

In: Nature Neuroscience, Vol. 8, No. 4, 04.2005, p. 413-414.

Research output: Contribution to journalArticle

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