TY - JOUR
T1 - Selenite nuclear cataractogenesis
T2 - A scanning electron microscope study
AU - Anderson, Ruth S.
AU - Shearer, Thomas R.
N1 - Funding Information:
ACKNOWLEDGEMENTS Partially supported by NIH Grant #EY03600 to T.R.S. The authors thank Mr. Mitsuoshi Azuma and Mr. Jay Wright for expert technical assistance.
PY - 1992
Y1 - 1992
N2 - The sequential changes during selenite nuclear cataractogenesis were examined with a scanning electron microscope (SEM) and correlated with slit lamp observations. A posterior opacity, visible with the slit lamp 1-2 days after injection of sodium selenite, was found to consist of masses of vacuoles in the superficial posterior cortex by SEM. 2-3 days post injection, a biomicroscopic refractile ring around the nucleus was represented by SEM abnormalities suggesting membrane damage and possible loss of cytosol in the perinuclear region. All normal structure in this region was lost by 5 days after injection when the central nucleus had become opaque. SEM also showed evidence for damage in areas which were still clear by slit lamp examination. Changes, characteristic of aging, were found near selenite induced damage in peripheral (younger) fibers.
AB - The sequential changes during selenite nuclear cataractogenesis were examined with a scanning electron microscope (SEM) and correlated with slit lamp observations. A posterior opacity, visible with the slit lamp 1-2 days after injection of sodium selenite, was found to consist of masses of vacuoles in the superficial posterior cortex by SEM. 2-3 days post injection, a biomicroscopic refractile ring around the nucleus was represented by SEM abnormalities suggesting membrane damage and possible loss of cytosol in the perinuclear region. All normal structure in this region was lost by 5 days after injection when the central nucleus had become opaque. SEM also showed evidence for damage in areas which were still clear by slit lamp examination. Changes, characteristic of aging, were found near selenite induced damage in peripheral (younger) fibers.
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U2 - 10.3109/02713689208999540
DO - 10.3109/02713689208999540
M3 - Article
C2 - 1337028
AN - SCOPUS:0027102664
SN - 0271-3683
VL - 11
SP - 1147
EP - 1160
JO - Current Eye Research
JF - Current Eye Research
IS - 12
ER -