Selenazolidines as novel organoselenium delivery agents

Yang Xie, Megan D. Short, Pamela B. Cassidy, Jeanette C. Roberts

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Two new classes of selenazolidine-4(R)-carboxylic acids (2-oxo and 2-methyl-SCAs) were synthesized and characterized. Both were designed as latent forms of selenocysteine, intended to provide a chemically superior delivery form for selenium. The prodrugs may be clinically useful when selenium supplementation at supranutritional levels is indicated, such as in cancer chemoprevention.

Original languageEnglish (US)
Pages (from-to)2911-2915
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Issue number22
StatePublished - Nov 19 2001
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


Dive into the research topics of 'Selenazolidines as novel organoselenium delivery agents'. Together they form a unique fingerprint.

Cite this