@article{2a7f02cc1e904c0ba74560f149b1174e,
title = "Selenazolidines as novel organoselenium delivery agents",
abstract = "Two new classes of selenazolidine-4(R)-carboxylic acids (2-oxo and 2-methyl-SCAs) were synthesized and characterized. Both were designed as latent forms of selenocysteine, intended to provide a chemically superior delivery form for selenium. The prodrugs may be clinically useful when selenium supplementation at supranutritional levels is indicated, such as in cancer chemoprevention.",
author = "Yang Xie and Short, {Megan D.} and Cassidy, {Pamela B.} and Roberts, {Jeanette C.}",
note = "Funding Information: Financial assistance by the University of Utah Research Committee, the Cancer Foundation of America, and the National Institutes of Health (GM58913) is gratefully acknowledged. We would also like to acknowledge NIH grants RR13030, RR06262 and RR14768 and NSF grant DBI-0002806 for funding NMR instrumentation in the University of Utah Health Sciences NMR Facility. The Finnegan MAT 95 mass spectrometer was supported by the University of Utah Institutional Funds Committee, and the Finnegan DECA instrument by the University of Utah Cancer Center Support Grant (CA42014) and the Huntsman Cancer Institute. Preliminary synthetic work on OSCA conducted by Dr. Ryan Van Wagoner was greatly appreciated. ",
year = "2001",
month = nov,
day = "19",
doi = "10.1016/S0960-894X(01)00590-X",
language = "English (US)",
volume = "11",
pages = "2911--2915",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "22",
}