Selegiline protects dopaminergic neurons in culture from toxic factor(s) present in the cerebrospinal fluid of patients with Parkinson's disease

R. Hao, M. Ebadi, Ronald Pfeiffer

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD) contains substance(s) that inhibit the growth and functions of dopaminergic neurons. Furthermore, selegiline, a monoamine oxidase B (MAO) inhibitor (0.125-0.250 μM) enhanced the number of tyrosine hydroxylase (TH)-positive neurons, augmented the high affinity uptake of dopamine (DA), and averted the neurotoxic effects of CSF of PD patients on rat mesencephalic neurons in culture. The neuroprotective effects of selegiline may be related either to its ability to inhibit MAO B, preventing the generation of free radicals, or to neuronal rescue property due to unknown mechanisms.

Original languageEnglish (US)
Pages (from-to)77-80
Number of pages4
JournalNeuroscience Letters
Volume200
Issue number2
DOIs
StatePublished - Nov 17 1995
Externally publishedYes

Fingerprint

Selegiline
Poisons
Dopaminergic Neurons
Monoamine Oxidase
Parkinson Disease
Cerebrospinal Fluid
Neurons
Monoamine Oxidase Inhibitors
Tyrosine 3-Monooxygenase
Neuroprotective Agents
Free Radicals
Dopamine
Growth

Keywords

  • Dopamine
  • Dopaminergic neurons
  • Monoamine oxidase B
  • Neuroprotection
  • Neurotoxicity
  • Oxidative stress
  • Selegiline

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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abstract = "The cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD) contains substance(s) that inhibit the growth and functions of dopaminergic neurons. Furthermore, selegiline, a monoamine oxidase B (MAO) inhibitor (0.125-0.250 μM) enhanced the number of tyrosine hydroxylase (TH)-positive neurons, augmented the high affinity uptake of dopamine (DA), and averted the neurotoxic effects of CSF of PD patients on rat mesencephalic neurons in culture. The neuroprotective effects of selegiline may be related either to its ability to inhibit MAO B, preventing the generation of free radicals, or to neuronal rescue property due to unknown mechanisms.",
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AU - Ebadi, M.

AU - Pfeiffer, Ronald

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