Selegiline protects dopaminergic neurons in culture from toxic factor(s) present in the cerebrospinal fluid of patients with Parkinson's disease

R. Hao, M. Ebadi, Ronald Pfeiffer

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Abstract

The cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD) contains substance(s) that inhibit the growth and functions of dopaminergic neurons. Furthermore, selegiline, a monoamine oxidase B (MAO) inhibitor (0.125-0.250 μM) enhanced the number of tyrosine hydroxylase (TH)-positive neurons, augmented the high affinity uptake of dopamine (DA), and averted the neurotoxic effects of CSF of PD patients on rat mesencephalic neurons in culture. The neuroprotective effects of selegiline may be related either to its ability to inhibit MAO B, preventing the generation of free radicals, or to neuronal rescue property due to unknown mechanisms.

Original languageEnglish (US)
Pages (from-to)77-80
Number of pages4
JournalNeuroscience Letters
Volume200
Issue number2
DOIs
Publication statusPublished - Nov 17 1995
Externally publishedYes

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Keywords

  • Dopamine
  • Dopaminergic neurons
  • Monoamine oxidase B
  • Neuroprotection
  • Neurotoxicity
  • Oxidative stress
  • Selegiline

ASJC Scopus subject areas

  • Neuroscience(all)

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