Selective tubal sterilization in rabbits

Experience with a hydrogel combined with a sclerosing agent

Antoine J. Maubon, Amy S. Thurmond, Alexandre Laurent, Jiri E. Honiger, Richard (Mick) Scanlan, Jean Pierre Rouanet

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

PURPOSE: To test a method of nonsurgical sterilization. MATERIALS AND METHODS: A hydrogel that forms an in situ plug by phase inversion of a polymer solution was placed into fallopian tubes of eight rabbits by means of transvaginal fluoroscopic fallopian tube catheterization. The rabbits were bred, and the presence of embryos was confirmed with palpation and at autopsy. RESULTS: Seven of the eight rabbits became pregnant. Six of these rabbits contained embryos in the control uterus but not in the uterus on the side of the hydrogel injection. The seventh rabbit had embryos in both uteri, but the hydrogel had been expelled. All seven tubes that contained hydrogel showed evidence of acute and chronic salpingitis and a foreign-body reaction. The tube from which hydrogel had been expelled and the eight control tubes were not inflamed. CONCLUSION: Transcervical catheter methods of tubal occlusion and sterilization are promising, but a non-reactive material is needed.

Original languageEnglish (US)
Pages (from-to)721-723
Number of pages3
JournalRadiology
Volume193
Issue number3
StatePublished - Dec 1994

Fingerprint

Sclerosing Solutions
Tubal Sterilization
Hydrogel
Rabbits
Uterus
Embryonic Structures
Fallopian Tubes
Salpingitis
Foreign-Body Reaction
Palpation
Catheterization
Autopsy
Polymers
Catheters
Injections

Keywords

  • Contraceptives and contraceptive devices
  • Fallopian tubes, interventional procedures
  • Interventional procedures, experimental

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Maubon, A. J., Thurmond, A. S., Laurent, A., Honiger, J. E., Scanlan, R. M., & Rouanet, J. P. (1994). Selective tubal sterilization in rabbits: Experience with a hydrogel combined with a sclerosing agent. Radiology, 193(3), 721-723.

Selective tubal sterilization in rabbits : Experience with a hydrogel combined with a sclerosing agent. / Maubon, Antoine J.; Thurmond, Amy S.; Laurent, Alexandre; Honiger, Jiri E.; Scanlan, Richard (Mick); Rouanet, Jean Pierre.

In: Radiology, Vol. 193, No. 3, 12.1994, p. 721-723.

Research output: Contribution to journalArticle

Maubon, AJ, Thurmond, AS, Laurent, A, Honiger, JE, Scanlan, RM & Rouanet, JP 1994, 'Selective tubal sterilization in rabbits: Experience with a hydrogel combined with a sclerosing agent', Radiology, vol. 193, no. 3, pp. 721-723.
Maubon AJ, Thurmond AS, Laurent A, Honiger JE, Scanlan RM, Rouanet JP. Selective tubal sterilization in rabbits: Experience with a hydrogel combined with a sclerosing agent. Radiology. 1994 Dec;193(3):721-723.
Maubon, Antoine J. ; Thurmond, Amy S. ; Laurent, Alexandre ; Honiger, Jiri E. ; Scanlan, Richard (Mick) ; Rouanet, Jean Pierre. / Selective tubal sterilization in rabbits : Experience with a hydrogel combined with a sclerosing agent. In: Radiology. 1994 ; Vol. 193, No. 3. pp. 721-723.
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