Selective thyromimetics: Tissue-selective thyroid hormone analogs

T. S. Scanlan, H. A. Yoshihara, N. H. Nguyen, G. Chiellini

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

Thyroid hormone coordinates a diverse array of physiological events in development and homeostasis. Many of the actions of thyroid hormone are tissue-specific and are primarily mediated by a panel of thyroid hormone receptor isoforms that are expressed in different ratios in different tissues. Because these tissue-specific hormone signaling pathways are linked to a number of metabolic diseases, the development of synthetic thyroid hormone analogs that have tissue-selective hormone actions (ie, selective thyromimetics) is highly desirable. There is a powerful collection of tools available today for this pursuit including efficient receptor binding and activation assays, receptor structures and a variety of thyroid hormone receptor knockout mice. The medicinal chemistry efforts in this area demonstrate that selective thyromimetics can be produced from a variety of approaches. These compounds are proving useful as probes to better define thyroid hormone actions and may one day find use in the clinic for the treatment of metabolic disorders.

Original languageEnglish (US)
Pages (from-to)614-622
Number of pages9
JournalCurrent Opinion in Drug Discovery and Development
Volume4
Issue number5
StatePublished - 2001

Keywords

  • Isoform-selective
  • Thyroid hormone
  • Thyroid hormone receptor
  • Thyromimetic
  • Tissue-selective

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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