Selective therapeutic hypothermia: a review of invasive and noninvasive techniques.

David Straus, Vinay Prasad, Lorenzo Munoz

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Therapeutic hypothermia is a promising treatment to prevent secondary neurologic injury. Clinical utility is limited by systemic complications of global hypothermia. Selective brain cooling remains a largely uninvestigated application. We review techniques of inducing selective brain cooling. Literature review. Strategies of inducing selective brain cooling were divided between non-invasive and invasive techniques. Non-invasive techniques were surface cooling and cooling via the upper airway. Invasive cooling methods include transvascular and compartmental (epidural, subdural, subarachnoid and intraventricular) cooling methods to remove heat from the brain. Selective brain cooling may offer the best strategy for achieving hypothermic neuroprotection. Non-invasive strategies have proven disappointing in human trials. There is a paucity of human experiments using invasive methods of selective brain cooling. Further application of invasive cooling strategies is needed.

Original languageEnglish (US)
Pages (from-to)981-987
Number of pages7
JournalArquivos de Neuro-Psiquiatria
Volume69
Issue number6
StatePublished - Dec 2011
Externally publishedYes

Fingerprint

Induced Hypothermia
Brain
Nervous System Trauma
Hypothermia
Hot Temperature

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry

Cite this

Selective therapeutic hypothermia : a review of invasive and noninvasive techniques. / Straus, David; Prasad, Vinay; Munoz, Lorenzo.

In: Arquivos de Neuro-Psiquiatria, Vol. 69, No. 6, 12.2011, p. 981-987.

Research output: Contribution to journalReview article

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