Selective therapeutic hypothermia: a review of invasive and noninvasive techniques.

David Straus, Vinay Prasad, Lorenzo Munoz

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Therapeutic hypothermia is a promising treatment to prevent secondary neurologic injury. Clinical utility is limited by systemic complications of global hypothermia. Selective brain cooling remains a largely uninvestigated application. We review techniques of inducing selective brain cooling. Literature review. Strategies of inducing selective brain cooling were divided between non-invasive and invasive techniques. Non-invasive techniques were surface cooling and cooling via the upper airway. Invasive cooling methods include transvascular and compartmental (epidural, subdural, subarachnoid and intraventricular) cooling methods to remove heat from the brain. Selective brain cooling may offer the best strategy for achieving hypothermic neuroprotection. Non-invasive strategies have proven disappointing in human trials. There is a paucity of human experiments using invasive methods of selective brain cooling. Further application of invasive cooling strategies is needed.

Original languageEnglish (US)
Pages (from-to)981-987
Number of pages7
JournalArquivos de neuro-psiquiatria
Issue number6
StatePublished - Dec 2011
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry


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