Selective targeting of GnRH-II neurons to block ovulation

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    3 Scopus citations

    Abstract

    Background: In rhesus macaques, luteinizing hormone (LH) secretion appears to be regulated by two distinct gonadotropin-releasing hormone (GnRH) neuronal populations, which can be distinguished by their unique anatomical locations and because they express different molecular forms of GnRH (GnRH-I and GnRH-II). Study Design: The effect of estradiol on GnRH gene expression was examined. Results: Estradiol inhibited GnRH-I neurons but stimulated GnRH-II neurons, suggesting that GnRH-II neurons play the dominant role in mediating estradiol-positive feedback and triggering the midcycle preovulatory LH surge. Conclusions: Selective silencing of GnRH-II neurons in women could serve as a novel contraceptive, by blocking ovulation while leaving the rest of the reproductive axis relatively unperturbed.

    Original languageEnglish (US)
    Pages (from-to)423-425
    Number of pages3
    JournalContraception
    Volume91
    Issue number5
    DOIs
    StatePublished - May 1 2015

    Keywords

    • Estradiol
    • Gonadotropin-releasing hormone
    • Luteinizing hormone
    • Rhesus macaque

    ASJC Scopus subject areas

    • Reproductive Medicine
    • Obstetrics and Gynecology

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