Selective muscarinic receptor antagonists for airway diseases

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Airway tone and airway hyperreactivity are mediated by the parasympathetic nerves that release acetylcholine onto muscarinic receptors (M1-M5). Stimulation of M1 and M3 muscarinic receptors causes bronchoconstriction. The M1 muscarinic receptor is excitatory, and facilitates neuronal transmission at the parasympathetic ganglion. The M2 receptor is an inhibitory prejunctional autoreceptor. The discovery of discrete muscarinic receptor subtypes prompted development of selective muscarinic receptor antagonists. Selective M3 receptor antagonists and antagonists selective for M1 and M3 receptors have recently entered clinical trials and offer much promise for the treatment of airways diseases.

Original languageEnglish (US)
Pages (from-to)223-229
Number of pages7
JournalCurrent Opinion in Pharmacology
Volume1
Issue number3
DOIs
StatePublished - Jun 1 2001
Externally publishedYes

Fingerprint

Muscarinic M1 Receptors
Muscarinic Antagonists
Muscarinic Receptors
Muscarinic M5 Receptors
Parasympathetic Ganglia
Muscarinic M3 Receptors
Autoreceptors
Bronchoconstriction
Acetylcholine
Clinical Trials

Keywords

  • Airways disease
  • Antimuscarinic bronchodilator
  • Asthma
  • Chronic obstructive lung disease
  • Molecular Medicine
  • Muscarinic receptor
  • Pharmacology
  • Review
  • Tiotropium

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Selective muscarinic receptor antagonists for airway diseases. / Lee, Ann M.; Jacoby, David; Fryer, Allison.

In: Current Opinion in Pharmacology, Vol. 1, No. 3, 01.06.2001, p. 223-229.

Research output: Contribution to journalArticle

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