Selective fluorescence labeling of lipids in living cells

Anne B. Neef, Carsten Schultz

Research output: Contribution to journalArticle

170 Scopus citations

Abstract

Click chemistry in vivo: Three phosphatidic acid derivatives with alkyne groups in their fatty acid chains weresynthesized and incorporated into mammalian cell membranes. Cooper(l) catalyzed and strain-promoted azide-alkyne cycloaddition reactions were used for their visualization (see schematic representation and flourescence microscopic image).-

Original languageEnglish (US)
Pages (from-to)1498-1500
Number of pages3
JournalAngewandte Chemie - International Edition
Volume48
Issue number8
DOIs
StatePublished - Feb 9 2009

Keywords

  • Alkynes
  • Click chemistry
  • Fluorescent probes
  • Phospholipids

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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