Selective fluorescence labeling of lipids in living cells

Anne B. Neef, Carsten Schultz

Research output: Contribution to journalArticle

160 Citations (Scopus)

Abstract

Click chemistry in vivo: Three phosphatidic acid derivatives with alkyne groups in their fatty acid chains weresynthesized and incorporated into mammalian cell membranes. Cooper(l) catalyzed and strain-promoted azide-alkyne cycloaddition reactions were used for their visualization (see schematic representation and flourescence microscopic image).-

Original languageEnglish (US)
Pages (from-to)1498-1500
Number of pages3
JournalAngewandte Chemie - International Edition
Volume48
Issue number8
DOIs
StatePublished - Feb 9 2009
Externally publishedYes

Fingerprint

Alkynes
Cycloaddition
Schematic diagrams
Cell membranes
Fatty acids
Labeling
Lipids
Visualization
Fluorescence
Cells
Derivatives
Phosphatidic Acids
Azides
Acids
Fatty Acids

Keywords

  • Alkynes
  • Click chemistry
  • Fluorescent probes
  • Phospholipids

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

Selective fluorescence labeling of lipids in living cells. / Neef, Anne B.; Schultz, Carsten.

In: Angewandte Chemie - International Edition, Vol. 48, No. 8, 09.02.2009, p. 1498-1500.

Research output: Contribution to journalArticle

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