Selective breeding for high and low levels of opiate-induced analgesia in mice

John Belknap, N. R. Haltli, D. M. Goebel, M. Lamé

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Beginning with a genetically heterogeneous outbred stock of mice (Binghamton HET), selective breeding was conducted within two selected lines for a high analgesic (antinociceptive) response and a low analgesic response, respectively, to a narcotic analgesic (levorphanol tartrate) using the hot-plate test. A nonselected control line was also maintained concurrently. Four generations of predominantly mass selection have produced a marked divergence between the two oppositely selected lines, yielding a realized heritability (h2) of 0.32±0.05. The selection response was markedly asymmetrical, with a realized h2 in the high direction of 0.45±0.10 and in the low direction of 0.12±0.07. These animals represent potentially useful subject material for research concerning the mechanisms and correlates of opiate-induced analgesia.

Original languageEnglish (US)
Pages (from-to)383-396
Number of pages14
JournalBehavior Genetics
Volume13
Issue number4
DOIs
StatePublished - Jul 1983
Externally publishedYes

Fingerprint

Opiate Alkaloids
selective breeding
analgesics
selection methods
analgesia
Analgesia
Analgesics
Levorphanol
selection response
Narcotics
mice
narcotics
heritability
divergence
animal
Research
animals
Selective Breeding
Direction compound

Keywords

  • analgesia
  • antinociception
  • hot plate test
  • levorphanol
  • mice
  • morphine
  • selection
  • selective breeding

ASJC Scopus subject areas

  • Psychology(all)
  • Behavioral Neuroscience
  • Genetics(clinical)
  • Genetics

Cite this

Selective breeding for high and low levels of opiate-induced analgesia in mice. / Belknap, John; Haltli, N. R.; Goebel, D. M.; Lamé, M.

In: Behavior Genetics, Vol. 13, No. 4, 07.1983, p. 383-396.

Research output: Contribution to journalArticle

Belknap, J, Haltli, NR, Goebel, DM & Lamé, M 1983, 'Selective breeding for high and low levels of opiate-induced analgesia in mice', Behavior Genetics, vol. 13, no. 4, pp. 383-396. https://doi.org/10.1007/BF01065776
Belknap, John ; Haltli, N. R. ; Goebel, D. M. ; Lamé, M. / Selective breeding for high and low levels of opiate-induced analgesia in mice. In: Behavior Genetics. 1983 ; Vol. 13, No. 4. pp. 383-396.
@article{4c9262833d6749258b3cecf573200843,
title = "Selective breeding for high and low levels of opiate-induced analgesia in mice",
abstract = "Beginning with a genetically heterogeneous outbred stock of mice (Binghamton HET), selective breeding was conducted within two selected lines for a high analgesic (antinociceptive) response and a low analgesic response, respectively, to a narcotic analgesic (levorphanol tartrate) using the hot-plate test. A nonselected control line was also maintained concurrently. Four generations of predominantly mass selection have produced a marked divergence between the two oppositely selected lines, yielding a realized heritability (h2) of 0.32±0.05. The selection response was markedly asymmetrical, with a realized h2 in the high direction of 0.45±0.10 and in the low direction of 0.12±0.07. These animals represent potentially useful subject material for research concerning the mechanisms and correlates of opiate-induced analgesia.",
keywords = "analgesia, antinociception, hot plate test, levorphanol, mice, morphine, selection, selective breeding",
author = "John Belknap and Haltli, {N. R.} and Goebel, {D. M.} and M. Lam{\'e}",
year = "1983",
month = "7",
doi = "10.1007/BF01065776",
language = "English (US)",
volume = "13",
pages = "383--396",
journal = "Behavior Genetics",
issn = "0001-8244",
publisher = "Springer New York",
number = "4",

}

TY - JOUR

T1 - Selective breeding for high and low levels of opiate-induced analgesia in mice

AU - Belknap, John

AU - Haltli, N. R.

AU - Goebel, D. M.

AU - Lamé, M.

PY - 1983/7

Y1 - 1983/7

N2 - Beginning with a genetically heterogeneous outbred stock of mice (Binghamton HET), selective breeding was conducted within two selected lines for a high analgesic (antinociceptive) response and a low analgesic response, respectively, to a narcotic analgesic (levorphanol tartrate) using the hot-plate test. A nonselected control line was also maintained concurrently. Four generations of predominantly mass selection have produced a marked divergence between the two oppositely selected lines, yielding a realized heritability (h2) of 0.32±0.05. The selection response was markedly asymmetrical, with a realized h2 in the high direction of 0.45±0.10 and in the low direction of 0.12±0.07. These animals represent potentially useful subject material for research concerning the mechanisms and correlates of opiate-induced analgesia.

AB - Beginning with a genetically heterogeneous outbred stock of mice (Binghamton HET), selective breeding was conducted within two selected lines for a high analgesic (antinociceptive) response and a low analgesic response, respectively, to a narcotic analgesic (levorphanol tartrate) using the hot-plate test. A nonselected control line was also maintained concurrently. Four generations of predominantly mass selection have produced a marked divergence between the two oppositely selected lines, yielding a realized heritability (h2) of 0.32±0.05. The selection response was markedly asymmetrical, with a realized h2 in the high direction of 0.45±0.10 and in the low direction of 0.12±0.07. These animals represent potentially useful subject material for research concerning the mechanisms and correlates of opiate-induced analgesia.

KW - analgesia

KW - antinociception

KW - hot plate test

KW - levorphanol

KW - mice

KW - morphine

KW - selection

KW - selective breeding

UR - http://www.scopus.com/inward/record.url?scp=0020617862&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020617862&partnerID=8YFLogxK

U2 - 10.1007/BF01065776

DO - 10.1007/BF01065776

M3 - Article

C2 - 6639563

AN - SCOPUS:0020617862

VL - 13

SP - 383

EP - 396

JO - Behavior Genetics

JF - Behavior Genetics

SN - 0001-8244

IS - 4

ER -