Selective breeding for ethanol-related traits alters circadian phenotype

Walter D. McCulley, Sonja Ascheid, John Jr Crabbe, Alan M. Rosenwasser

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Previous studies in mice and rats have shown that selective breeding for high and low ethanol preference results in divergence of circadian phenotype in the selected lines. These results indicate that some alleles influencing ethanol preference also contribute to circadian rhythm regulation. Selective breeding has also been used to produce lines of mice differing in a number of other ethanol-related traits, while studies of phenotypic and genetic correlation indicate that diverse ethanol-related traits are influenced by both shared and unshared genetics. In the present study, we examined several features of circadian activity rhythms in a mouse line selected for binge-like drinking and in mouse lines selected for high and low severity of ethanol withdrawal convulsions. Specifically, Experiment 1 compared High Drinking in the Dark (HDID-1) mice to their genetically heterogeneous progenitor line (HS/Npt), and Experiment 2 compared Withdrawal Seizure-Prone (WSP-2) and Withdrawal Seizure-Resistant (WSR-2) mice. Both line pairs displayed differences in their daily activity patterns under light-dark conditions. In addition, HDID-1 mice showed shorter free-running periods in constant light and less coherent activity rhythms across lighting conditions relative to HS/Npt controls, while WSP-2 mice showed longer free-running periods in constant darkness relative to WSR-2 mice. These results strengthen the evidence for genetic linkages between responsiveness to ethanol and circadian regulation, and extend this evidence to include ethanol-related phenotypes other than preference drinking. However, the present results also indicate that the nature of genetic correlations between and within phenotypic domains is highly complex.

Original languageEnglish (US)
Pages (from-to)187-194
Number of pages8
JournalAlcohol
Volume47
Issue number3
DOIs
StatePublished - May 2013

Fingerprint

Ethanol
withdrawal
Phenotype
seizure
regulation
experiment
Seizures
work environment
divergence
Circadian Rhythm
evidence
Drinking
Binge Drinking
Selective Breeding
Light
Genetic Linkage
Darkness
Rats
Lighting
Experiments

Keywords

  • Binge drinking
  • Circadian activity rhythms
  • Ethanol withdrawal
  • Selective breeding

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)
  • Behavioral Neuroscience
  • Neurology
  • Toxicology
  • Health(social science)

Cite this

Selective breeding for ethanol-related traits alters circadian phenotype. / McCulley, Walter D.; Ascheid, Sonja; Crabbe, John Jr; Rosenwasser, Alan M.

In: Alcohol, Vol. 47, No. 3, 05.2013, p. 187-194.

Research output: Contribution to journalArticle

McCulley, Walter D. ; Ascheid, Sonja ; Crabbe, John Jr ; Rosenwasser, Alan M. / Selective breeding for ethanol-related traits alters circadian phenotype. In: Alcohol. 2013 ; Vol. 47, No. 3. pp. 187-194.
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