Abstract
Mouse lines have been genetically selected to be alcohol Withdrawal Seizure Prone (WSP) or Resistant (WSR). The selection index is the severity of withdrawal handling-induced convulsions seen after removal of mice from chronic exposure to ethanol vapor. Behavioral, pharmacological, and neurochemical results from a replicated bidirectional selection project are reviewed. In reciprocal F1 crosses of the WSP and WSR lines, substantial dominance for resistance to withdrawal was found in both replicated sets of lines. WSP and WSR mice differ principally, and markedly, in traits related to the severity of withdrawal from alcohols and other drugs with depressant properties. This suggests that genes influencing severity of withdrawal from chronic ethanol exposure also pleiotropically influence genetic susceptibility to dependence on other drugs of abuse. However, the results of WSP vs. WSR comparisons for traits related to ethanol sensitivity and tolerance development suggest control in large part by genes different from those influencing withdrawal severity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 171-177 |
| Number of pages | 7 |
| Journal | Behavior Genetics |
| Volume | 23 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 1993 |
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Keywords
- acute withdrawal
- ethanol
- seizure susceptibility
- tolerance
- Withdrawal Seizure Prone (WSP)- and Resistant (WSR)- selected lines
ASJC Scopus subject areas
- Psychology(all)
- Behavioral Neuroscience
- Genetics(clinical)
- Genetics
Cite this
Selective breeding for alcohol withdrawal severity. / Crabbe, John Jr; Phillips, Tamara.
In: Behavior Genetics, Vol. 23, No. 2, 03.1993, p. 171-177.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Selective breeding for alcohol withdrawal severity
AU - Crabbe, John Jr
AU - Phillips, Tamara
PY - 1993/3
Y1 - 1993/3
N2 - Mouse lines have been genetically selected to be alcohol Withdrawal Seizure Prone (WSP) or Resistant (WSR). The selection index is the severity of withdrawal handling-induced convulsions seen after removal of mice from chronic exposure to ethanol vapor. Behavioral, pharmacological, and neurochemical results from a replicated bidirectional selection project are reviewed. In reciprocal F1 crosses of the WSP and WSR lines, substantial dominance for resistance to withdrawal was found in both replicated sets of lines. WSP and WSR mice differ principally, and markedly, in traits related to the severity of withdrawal from alcohols and other drugs with depressant properties. This suggests that genes influencing severity of withdrawal from chronic ethanol exposure also pleiotropically influence genetic susceptibility to dependence on other drugs of abuse. However, the results of WSP vs. WSR comparisons for traits related to ethanol sensitivity and tolerance development suggest control in large part by genes different from those influencing withdrawal severity.
AB - Mouse lines have been genetically selected to be alcohol Withdrawal Seizure Prone (WSP) or Resistant (WSR). The selection index is the severity of withdrawal handling-induced convulsions seen after removal of mice from chronic exposure to ethanol vapor. Behavioral, pharmacological, and neurochemical results from a replicated bidirectional selection project are reviewed. In reciprocal F1 crosses of the WSP and WSR lines, substantial dominance for resistance to withdrawal was found in both replicated sets of lines. WSP and WSR mice differ principally, and markedly, in traits related to the severity of withdrawal from alcohols and other drugs with depressant properties. This suggests that genes influencing severity of withdrawal from chronic ethanol exposure also pleiotropically influence genetic susceptibility to dependence on other drugs of abuse. However, the results of WSP vs. WSR comparisons for traits related to ethanol sensitivity and tolerance development suggest control in large part by genes different from those influencing withdrawal severity.
KW - acute withdrawal
KW - ethanol
KW - seizure susceptibility
KW - tolerance
KW - Withdrawal Seizure Prone (WSP)- and Resistant (WSR)- selected lines
UR - http://www.scopus.com/inward/record.url?scp=0027276518&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027276518&partnerID=8YFLogxK
U2 - 10.1007/BF01067422
DO - 10.1007/BF01067422
M3 - Article
C2 - 8512531
AN - SCOPUS:0027276518
VL - 23
SP - 171
EP - 177
JO - Behavior Genetics
JF - Behavior Genetics
SN - 0001-8244
IS - 2
ER -