Selective androgen receptor modulators antagonize apolipoprotein E4-induced cognitive impairments

Summer Acevedo, Luis Gardell, Stefania Risso Bradley, Fabrice Piu, Jacob Raber

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

While tissue specific effects of selective androgen receptor modulators (SARMs) outside the brain have been reported, little is known about brain specific SARMs. Here we show that SARMs upregulate androgen receptor levels in brain following castration and antagonize impairments in hippocampus-dependent novel location recognition and spatial memory retention in apoE4 female mice. Together with the reduced androgen levels in aged men and women and the beneficial effects of androgens on brain function and pathology in Alzheimer's disease-related models, these data support the therapeutic potential of SARMs for age-related cognitive decline and Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)271-276
Number of pages6
JournalLetters in Drug Design and Discovery
Volume5
Issue number4
DOIs
StatePublished - Jun 1 2008

Keywords

  • Androgen receptor
  • Castration
  • Mouse
  • Object recognition
  • Open field
  • Water maze

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

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