Selective activation of mGluR8 receptors modulates retinal ganglion cell light responses

S. Quraishi, B. T. Reed, R. M. Duvoisin, W. R. Taylor

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Extracellular and whole-cell light-evoked responses of mouse retinal ganglion cells were recorded in the presence of the mGluR8 selective agonist, (S)-3,4-dicarboxy-phenylglycine (DCPG). Off-light responses were reversibly reduced in the presence of DCPG in wild-type but not in mGluR8-deficient retinas. On-responses were only marginally modulated by DCPG. During Off-responses, DCPG suppressed both excitatory and inhibitory synaptic conductances suggesting that mGluR8 receptor activity reduces glutamate release from bipolar cell terminals and possibly also the release of an inhibitory neurotransmitter from amacrine cell processes.

Original languageEnglish (US)
Pages (from-to)935-941
Number of pages7
JournalNeuroscience
Volume166
Issue number3
DOIs
StatePublished - Mar 31 2010

Keywords

  • metabotropic glutamate receptor
  • retina

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Selective activation of mGluR8 receptors modulates retinal ganglion cell light responses'. Together they form a unique fingerprint.

  • Cite this