Selected mouse lines, alcohol and behavior

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

The technique of selective breeding has been employed to develop a number of mouse lines differing in genetic sensitivity to specific effects of ethanol. Genetic animal models for sensitivity to the hypnotic, thermoregulatory, excitatory, and dependence-producing effects of alcohol have been developed. These genetic animal models have been utilized in numerous studies to assess the bases for those genetic differences, and to determine the specific neurochemical and neurophysiological bases for ethanol's actions. Work with these lines has challenged some long-held beliefs about ethanol's mechanisms of action. For example, lines genetically sensitive to one effect of ethanol are not necessarily sensitive to others, which demonstrates that no single set of genes modulates all ethanol effects. LS mice, selected for sensitivity to ethanol anesthesia, are not similarly sensitive to all anesthetic drugs, which demonstrates that all such drugs cannot have a common mechanism of action. On the other hand, WSP mice, genetically susceptible to the development of severe ethanol withdrawal, show a similar predisposition to diazepam and phenobarbital withdrawal, which suggests that there may be a common set of genes underlying drug dependentcies. Studies with these models have also revealed important new directions for future mechanism-oriented research. Several studies implicate brain gamma-aminobutyric acid and dopamine systems as potentially important mediators of susceptibility to alcohol intoxication. The stability of the genetic animal models across laboratories and generations will continue to increase their power as analytic tools.

Original languageEnglish (US)
Pages (from-to)805-827
Number of pages23
JournalExperientia
Volume45
Issue number9
DOIs
StatePublished - Sep 1989

Fingerprint

Ethanol
Alcohols
Genetic Models
Animals
Animal Models
Genes
Alcoholic Intoxication
Phenobarbital
Diazepam
Hypnotics and Sedatives
Pharmaceutical Preparations
gamma-Aminobutyric Acid
Anesthetics
Dopamine
Brain
Anesthesia
Research

Keywords

  • ethanol effects
  • long-sleep mouse
  • Mouse lines
  • pharmacogenetics
  • selective breeding
  • short-sleep mouse

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Selected mouse lines, alcohol and behavior. / Phillips, Tamara; Feller, D. J.; Crabbe, John Jr.

In: Experientia, Vol. 45, No. 9, 09.1989, p. 805-827.

Research output: Contribution to journalArticle

Phillips, Tamara ; Feller, D. J. ; Crabbe, John Jr. / Selected mouse lines, alcohol and behavior. In: Experientia. 1989 ; Vol. 45, No. 9. pp. 805-827.
@article{0defe75df95249b89c9674e3472472cf,
title = "Selected mouse lines, alcohol and behavior",
abstract = "The technique of selective breeding has been employed to develop a number of mouse lines differing in genetic sensitivity to specific effects of ethanol. Genetic animal models for sensitivity to the hypnotic, thermoregulatory, excitatory, and dependence-producing effects of alcohol have been developed. These genetic animal models have been utilized in numerous studies to assess the bases for those genetic differences, and to determine the specific neurochemical and neurophysiological bases for ethanol's actions. Work with these lines has challenged some long-held beliefs about ethanol's mechanisms of action. For example, lines genetically sensitive to one effect of ethanol are not necessarily sensitive to others, which demonstrates that no single set of genes modulates all ethanol effects. LS mice, selected for sensitivity to ethanol anesthesia, are not similarly sensitive to all anesthetic drugs, which demonstrates that all such drugs cannot have a common mechanism of action. On the other hand, WSP mice, genetically susceptible to the development of severe ethanol withdrawal, show a similar predisposition to diazepam and phenobarbital withdrawal, which suggests that there may be a common set of genes underlying drug dependentcies. Studies with these models have also revealed important new directions for future mechanism-oriented research. Several studies implicate brain gamma-aminobutyric acid and dopamine systems as potentially important mediators of susceptibility to alcohol intoxication. The stability of the genetic animal models across laboratories and generations will continue to increase their power as analytic tools.",
keywords = "ethanol effects, long-sleep mouse, Mouse lines, pharmacogenetics, selective breeding, short-sleep mouse",
author = "Tamara Phillips and Feller, {D. J.} and Crabbe, {John Jr}",
year = "1989",
month = "9",
doi = "10.1007/BF01954056",
language = "English (US)",
volume = "45",
pages = "805--827",
journal = "Cellular and Molecular Life Sciences",
issn = "1420-682X",
publisher = "Birkhauser Verlag Basel",
number = "9",

}

TY - JOUR

T1 - Selected mouse lines, alcohol and behavior

AU - Phillips, Tamara

AU - Feller, D. J.

AU - Crabbe, John Jr

PY - 1989/9

Y1 - 1989/9

N2 - The technique of selective breeding has been employed to develop a number of mouse lines differing in genetic sensitivity to specific effects of ethanol. Genetic animal models for sensitivity to the hypnotic, thermoregulatory, excitatory, and dependence-producing effects of alcohol have been developed. These genetic animal models have been utilized in numerous studies to assess the bases for those genetic differences, and to determine the specific neurochemical and neurophysiological bases for ethanol's actions. Work with these lines has challenged some long-held beliefs about ethanol's mechanisms of action. For example, lines genetically sensitive to one effect of ethanol are not necessarily sensitive to others, which demonstrates that no single set of genes modulates all ethanol effects. LS mice, selected for sensitivity to ethanol anesthesia, are not similarly sensitive to all anesthetic drugs, which demonstrates that all such drugs cannot have a common mechanism of action. On the other hand, WSP mice, genetically susceptible to the development of severe ethanol withdrawal, show a similar predisposition to diazepam and phenobarbital withdrawal, which suggests that there may be a common set of genes underlying drug dependentcies. Studies with these models have also revealed important new directions for future mechanism-oriented research. Several studies implicate brain gamma-aminobutyric acid and dopamine systems as potentially important mediators of susceptibility to alcohol intoxication. The stability of the genetic animal models across laboratories and generations will continue to increase their power as analytic tools.

AB - The technique of selective breeding has been employed to develop a number of mouse lines differing in genetic sensitivity to specific effects of ethanol. Genetic animal models for sensitivity to the hypnotic, thermoregulatory, excitatory, and dependence-producing effects of alcohol have been developed. These genetic animal models have been utilized in numerous studies to assess the bases for those genetic differences, and to determine the specific neurochemical and neurophysiological bases for ethanol's actions. Work with these lines has challenged some long-held beliefs about ethanol's mechanisms of action. For example, lines genetically sensitive to one effect of ethanol are not necessarily sensitive to others, which demonstrates that no single set of genes modulates all ethanol effects. LS mice, selected for sensitivity to ethanol anesthesia, are not similarly sensitive to all anesthetic drugs, which demonstrates that all such drugs cannot have a common mechanism of action. On the other hand, WSP mice, genetically susceptible to the development of severe ethanol withdrawal, show a similar predisposition to diazepam and phenobarbital withdrawal, which suggests that there may be a common set of genes underlying drug dependentcies. Studies with these models have also revealed important new directions for future mechanism-oriented research. Several studies implicate brain gamma-aminobutyric acid and dopamine systems as potentially important mediators of susceptibility to alcohol intoxication. The stability of the genetic animal models across laboratories and generations will continue to increase their power as analytic tools.

KW - ethanol effects

KW - long-sleep mouse

KW - Mouse lines

KW - pharmacogenetics

KW - selective breeding

KW - short-sleep mouse

UR - http://www.scopus.com/inward/record.url?scp=0024430271&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024430271&partnerID=8YFLogxK

U2 - 10.1007/BF01954056

DO - 10.1007/BF01954056

M3 - Article

C2 - 2570713

AN - SCOPUS:0024430271

VL - 45

SP - 805

EP - 827

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

SN - 1420-682X

IS - 9

ER -