Segmental Mandibular Regeneration by Distraction Osteogenesis: An Experimental Study

Peter D. Costantino, George Shybut, Craig D. Friedman, Harold J. Pelzer, Michael Masini, Maisie Shindo, George A. Sisson

Research output: Contribution to journalArticle

183 Citations (Scopus)

Abstract

• We report the use of distraction osteogenesis for segmental mandibular regeneration. This technique has been used in thousands of patients in the Soviet Union to regenerate as much as 30 cm of tubular bone in the extremities. However, we are unaware of previous experimental or clinical reports of segmental mandibular regeneration by distraction osteogenesis. In a canine model, 2.5-cm segmental mandibular defects were filled with regenerate bone in 25 days at a rate of 1.0 mm/d using bifocal distraction osteogenesis. The diameters of the regenerate segments were comparable with preexisting mandi ble, and all animals resumed normal oromandibular function following regeneration. The regenerate bone was evaluated radiographically, angiographically, and histologically. In the control group without distraction osteogenesis, the segmental defects failed to fill with regenerate bone. The theoretical basis for distraction osteogenesis, a detailed description of the technique, and a review of previous studies on experimental mandibular lengthening are presented. (Arch Otolaryngol Head Neck Surg. 1990;116:535-545).

Original languageEnglish (US)
Pages (from-to)535-545
Number of pages11
JournalArchives of Otolaryngology - Head and Neck Surgery
Volume116
Issue number5
DOIs
StatePublished - 1990
Externally publishedYes

Fingerprint

Distraction Osteogenesis
Regeneration
Bone and Bones
USSR
Canidae
Extremities
Head
Control Groups

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery

Cite this

Segmental Mandibular Regeneration by Distraction Osteogenesis : An Experimental Study. / Costantino, Peter D.; Shybut, George; Friedman, Craig D.; Pelzer, Harold J.; Masini, Michael; Shindo, Maisie; Sisson, George A.

In: Archives of Otolaryngology - Head and Neck Surgery, Vol. 116, No. 5, 1990, p. 535-545.

Research output: Contribution to journalArticle

Costantino, Peter D. ; Shybut, George ; Friedman, Craig D. ; Pelzer, Harold J. ; Masini, Michael ; Shindo, Maisie ; Sisson, George A. / Segmental Mandibular Regeneration by Distraction Osteogenesis : An Experimental Study. In: Archives of Otolaryngology - Head and Neck Surgery. 1990 ; Vol. 116, No. 5. pp. 535-545.
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