Secular increase in placental weight in Saudi Arabia

S. H. Alwasel, Z. Abotalib, J. S. Aljarallah, C. Osmond, S. M. Alkharaz, I. M. Alhazza, A. Harrath, Kent Thornburg, D. J P Barker

    Research output: Contribution to journalArticle

    21 Citations (Scopus)

    Abstract

    Background: Ramadan is an annual period of day-time fasting during which people in Saudi Arabia, including pregnant women, change their diets and physical activity. We recently reported that among babies who were in the second or third trimester of gestation during Ramadan placental growth slowed. We also found that, over the four years of the study, placental weight increased by 29 g per year. We have now extended our data collection in order to examine this trend in more detail. Methods: We studied the birth records of 17 660 singletons born in King Saud Hospital, Unizah, Saudi Arabia, over a ten year period. The records included birth weight, placental weight and gestational age. Results: During the first six years of the study period mean placental weight rose by more than 100 g while mean birth weight was unchanged. This secular increase in placental weight was accompanied by a change in the placenta's response to Ramadan. During the first half of the study period babies who were in their second or third trimester of gestation during Ramadan had reduced placental weight (475 g and 476 g compared with 484 g, p <0.001 for both). During the second half of the study period babies who were in their first trimester of gestation during Ramadan had reduced placental weight (533 g compared with 539 g, p = 0.03). Conclusions: We suggest that the secular increase in placental weight reflects changes in maternal body composition. These have altered placental responses to the dietary changes during Ramadan. The biological processes underlying these responses are not known.

    Original languageEnglish (US)
    Pages (from-to)391-394
    Number of pages4
    JournalPlacenta
    Volume32
    Issue number5
    DOIs
    StatePublished - May 2011

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    Saudi Arabia
    Weights and Measures
    Third Pregnancy Trimester
    Second Pregnancy Trimester
    Birth Weight
    Pregnancy
    Birth Certificates
    Biological Phenomena
    First Pregnancy Trimester
    Body Composition
    Placenta
    Gestational Age
    Pregnant Women
    Fasting
    Mothers
    Exercise
    Diet
    Growth

    Keywords

    • Fetal programming
    • Placental weight
    • Placental/birth weight ratio
    • Ramadan

    ASJC Scopus subject areas

    • Obstetrics and Gynecology
    • Reproductive Medicine
    • Developmental Biology

    Cite this

    Alwasel, S. H., Abotalib, Z., Aljarallah, J. S., Osmond, C., Alkharaz, S. M., Alhazza, I. M., ... Barker, D. J. P. (2011). Secular increase in placental weight in Saudi Arabia. Placenta, 32(5), 391-394. https://doi.org/10.1016/j.placenta.2011.02.007

    Secular increase in placental weight in Saudi Arabia. / Alwasel, S. H.; Abotalib, Z.; Aljarallah, J. S.; Osmond, C.; Alkharaz, S. M.; Alhazza, I. M.; Harrath, A.; Thornburg, Kent; Barker, D. J P.

    In: Placenta, Vol. 32, No. 5, 05.2011, p. 391-394.

    Research output: Contribution to journalArticle

    Alwasel, SH, Abotalib, Z, Aljarallah, JS, Osmond, C, Alkharaz, SM, Alhazza, IM, Harrath, A, Thornburg, K & Barker, DJP 2011, 'Secular increase in placental weight in Saudi Arabia', Placenta, vol. 32, no. 5, pp. 391-394. https://doi.org/10.1016/j.placenta.2011.02.007
    Alwasel SH, Abotalib Z, Aljarallah JS, Osmond C, Alkharaz SM, Alhazza IM et al. Secular increase in placental weight in Saudi Arabia. Placenta. 2011 May;32(5):391-394. https://doi.org/10.1016/j.placenta.2011.02.007
    Alwasel, S. H. ; Abotalib, Z. ; Aljarallah, J. S. ; Osmond, C. ; Alkharaz, S. M. ; Alhazza, I. M. ; Harrath, A. ; Thornburg, Kent ; Barker, D. J P. / Secular increase in placental weight in Saudi Arabia. In: Placenta. 2011 ; Vol. 32, No. 5. pp. 391-394.
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    AU - Aljarallah, J. S.

    AU - Osmond, C.

    AU - Alkharaz, S. M.

    AU - Alhazza, I. M.

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