Abstract
Therapeutic options for patients with multiple myeloma whose disease has relapsed after a prior auto-SCT include novel biologic therapies, traditional chemotherapy or a second transplant, with no clear standard of care. Few published studies address the safety and efficacy of a second auto-SCT for relapsed disease. We reviewed the Abramson Cancer Center experience with salvage auto-SCT for relapsed multiple myeloma. Forty-one patients had received a salvage auto-SCT at our institution; the median time between transplants was 37 months (range 3-91). The overall response rate in assessable patients was 55%, and treatment-related mortality was 7%. With a median follow-up time of 15 months, the median PFS was 8.5 months and the median overall survival (OS) was 20.7 months. In a multivariate analysis of OS, independent prognostic factors were ≤ 5 prior lines of therapy and time to progression after initial auto-SCT of ≤ 12 months. We conclude that in well-selected patients, salvage auto-SCT is safe and effective for relapsed myeloma.
Original language | English (US) |
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Pages (from-to) | 417-422 |
Number of pages | 6 |
Journal | Bone marrow transplantation |
Volume | 43 |
Issue number | 5 |
DOIs | |
State | Published - 2009 |
Externally published | Yes |
ASJC Scopus subject areas
- Hematology
- Transplantation