Seasonality and pituitary volume

Paul J. Schwartz, Justin A. Loe, Craig N. Bash, Karen Bove, Erick H. Turner, Joseph A. Frank, Thomas A. Wehr, Norman E. Rosenthal

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Pituitary volume in humans has been reported to change size in response to experimental manipulations of photoperiod, and to be increased during an episode of non-seasonal major depression. We wanted to determine whether pituitary volume changes either across the seasons or during an episode of winter depression. Nineteen patients with winter-seasonal affective disorder and 19 sex-, age-, height-, and weight-matched controls underwent magnetic resonance imaging of the pituitary gland in both winter and summer. Images were obtained using 0.7-mm contiguous slices and the areas of all slices were summed to compute the final volume for each gland. We found no main effects or interactions involving either diagnosis or season in our primary analysis. In a post-hoc analysis, we found a trend towards a season x gender effect (P = 0.06), such that pituitary volume increased slightly (+4.0%) across seasons in women, whereas it decreased slightly (-4.3%) across seasons in men. The results suggest that neither winter depression nor the change of seasons is associated with a significant change in pituitary size.

Original languageEnglish (US)
Pages (from-to)151-157
Number of pages7
JournalPsychiatry Research - Neuroimaging
Volume74
Issue number3
DOIs
StatePublished - Jul 4 1997

Keywords

  • Depression
  • Gender
  • Magnetic resonance imaging
  • Photoperiod
  • Reproduction
  • Seasonal affective disorder

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

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    Schwartz, P. J., Loe, J. A., Bash, C. N., Bove, K., Turner, E. H., Frank, J. A., Wehr, T. A., & Rosenthal, N. E. (1997). Seasonality and pituitary volume. Psychiatry Research - Neuroimaging, 74(3), 151-157. https://doi.org/10.1016/S0925-4927(97)00015-2