Screening for hypertension in children and adolescents to prevent cardiovascular disease

Matthew Thompson, Tracy Dana, Christina Bougatsos, Ian Blazina, Susan L. Norris

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

BACKGROUND AND OBJECTIVE: The prevalence of hypertension is increasing in children, and may persist into adulthood. This systematic review was conducted for the US Preventive Services Task Force recommendation on the effectiveness of screening asymptomatic children and adolescents for hypertension in order to prevent cardiovascular disease. METHODS: Eligible studies were identified from Medline and the Cochrane Library (through July 2012). We included trials and controlled observational studies in asymptomatic children and adolescents on the effectiveness and harms of screening and treatment, as well as accuracy of blood pressure measurement. One author extracted study characteristics and results, which were checked for accuracy by a second author. RESULTS: No studies evaluated the effects of screening for hypertension on health outcomes. Two studies of screening tests for elevated blood pressure reported moderate sensitivities (0.65, 0.72) and specificities (0.75, 0.92). Sensitivities and specificities of child hypertension for the later presence of adult hypertension (7 studies) were wide ranging (0-0.63 and 0.77-1.0, respectively), and associations between child hypertension and carotid intima media thickening and proteinuria in young adults (3 studies) were inconsistent. Seven studies reported that drug interventions effectively lowered blood pressure in adolescents over short follow-up periods. No serious treatmentrelated adverse effects were reported. CONCLUSIONS: There is no direct evidence that screening for hypertension in children and adolescents reduces adverse cardiovascular outcomes in adults. Additional studies are needed to improve diagnosis and risk stratification of children with elevated blood pressure and to quantify risks and benefits of interventions.

Original languageEnglish (US)
Pages (from-to)490-525
Number of pages36
JournalPediatrics
Volume131
Issue number3
DOIs
StatePublished - Mar 2013

Fingerprint

Cardiovascular Diseases
Hypertension
Blood Pressure
Advisory Committees
Screening
Cardiovascular Disease
Proteinuria
Libraries
Observational Studies
Young Adult
Sensitivity and Specificity
Health
Pharmaceutical Preparations
Specificity

Keywords

  • Adolescents
  • Children
  • Drug
  • Hypertension
  • Lifestyle
  • Screening
  • Treatment

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Arts and Humanities (miscellaneous)

Cite this

Thompson, M., Dana, T., Bougatsos, C., Blazina, I., & Norris, S. L. (2013). Screening for hypertension in children and adolescents to prevent cardiovascular disease. Pediatrics, 131(3), 490-525. https://doi.org/10.1542/peds.2012-3523

Screening for hypertension in children and adolescents to prevent cardiovascular disease. / Thompson, Matthew; Dana, Tracy; Bougatsos, Christina; Blazina, Ian; Norris, Susan L.

In: Pediatrics, Vol. 131, No. 3, 03.2013, p. 490-525.

Research output: Contribution to journalArticle

Thompson, M, Dana, T, Bougatsos, C, Blazina, I & Norris, SL 2013, 'Screening for hypertension in children and adolescents to prevent cardiovascular disease', Pediatrics, vol. 131, no. 3, pp. 490-525. https://doi.org/10.1542/peds.2012-3523
Thompson, Matthew ; Dana, Tracy ; Bougatsos, Christina ; Blazina, Ian ; Norris, Susan L. / Screening for hypertension in children and adolescents to prevent cardiovascular disease. In: Pediatrics. 2013 ; Vol. 131, No. 3. pp. 490-525.
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