Screening digital rectal examination and prostate cancer mortality

A case-control study

Kathryn E. Richert-Boe, Linda Humphrey, Andrew G. Glass, Noel S. Weiss

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background-Prostate cancer is the second most common cause of death from cancer in men in the United States. Digital rectal examination is the oldest and most commonly used screening test for prostate cancer, but as yet there are no studies which demonstrate its effectiveness. Methods-A case-control study was conducted among members of a large health maintenance organisation to estimate the effect of screening digital rectal examination on mortality from prostate cancer. 150 men, aged 40-84 when cancer was diagnosed, who developed fatal prostate cancer, and 299 male controls matched for age who did not die from prostate cancer were studied. A history of screening digital rectal examination during the 10 years before the date on which cancer was diagnosed was determined from medical records. Results-A similar proportion of men who died from prostate cancer and controls had undergone at least one screening digital rectal examination during the 10 year interval (odds ratio = 0.84, 95% confidence interval 0.48 to 1.46). Similar results were obtained when a shorter interval (such as five years before diagnosis) during which screening histories were evaluated was considered, or in analyses in which men with a history of benign prostatic hypertrophy were excluded. Conclusions-The data suggest that screening digital rectal examination does not reduce mortality from prostate cancer to any appreciable degree.

Original languageEnglish (US)
Pages (from-to)99-103
Number of pages5
JournalJournal of Medical Screening
Volume5
Issue number2
StatePublished - 1998

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Digital Rectal Examination
Rectal Neoplasms
Case-Control Studies
Prostatic Neoplasms
Mortality
Neoplasms
Health Maintenance Organizations
Prostatic Hyperplasia
Medical Records
Cause of Death
Odds Ratio
Confidence Intervals

Keywords

  • Case-control study
  • Digital rectal examination
  • Prostate cancer

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Screening digital rectal examination and prostate cancer mortality : A case-control study. / Richert-Boe, Kathryn E.; Humphrey, Linda; Glass, Andrew G.; Weiss, Noel S.

In: Journal of Medical Screening, Vol. 5, No. 2, 1998, p. 99-103.

Research output: Contribution to journalArticle

Richert-Boe, Kathryn E. ; Humphrey, Linda ; Glass, Andrew G. ; Weiss, Noel S. / Screening digital rectal examination and prostate cancer mortality : A case-control study. In: Journal of Medical Screening. 1998 ; Vol. 5, No. 2. pp. 99-103.
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