Sclerosing hemangioma of the lung in a young woman with cutaneous melanoma

The role of electron microscopy in preventing an erroneous diagnosis of metastasis

Douglas Weeks, Samuel P. Hammar, Anne E. Rader, Richelle Malott, Gary W. Mierau

Research output: Contribution to journalArticle

Abstract

A young woman with a melanoma of the left forearm was found to have a right lung mass. This was initially interpreted as metastatic melanoma on the basis of clinical, radiographic, and light microscopic features, together with positive staining of tumor cells with antibody HMB-45. Electron microscopic examination performed for confirmation of the diagnosis revealed no evidence of melanocytic differentiation. Instead, there were features suggestive of the alternative diagnosis of sclerosing hemangioma (SH). This diagnosis was confirmed with additional immunocytochemical stains. To the authors' knowledge this is the first report of HMB-45 positivity in SH. This case illustrates a potentially disastrous diagnostic pitfall in interpreting lung tumors in patients with melanoma, and the vital role of electron microscopy in resolving conflicting and/or misleading immunocytochemical results.

Original languageEnglish (US)
Pages (from-to)261-265
Number of pages5
JournalUltrastructural Pathology
Volume26
Issue number4
DOIs
StatePublished - Jul 2002

Fingerprint

Pulmonary Sclerosing Hemangioma
metastasis
lungs
Benign Fibrous Histiocytoma
Electron microscopy
Melanoma
electron microscopy
Electron Microscopy
Neoplasm Metastasis
Skin
Tumors
tumors
forearm
Lung
staining
antibodies
Forearm
Antibodies
Neoplasms
Microscopic examination

Keywords

  • Electron microscopy
  • HMB-45
  • Melanoma
  • Sclerosing hemangioma

ASJC Scopus subject areas

  • Structural Biology
  • Pathology and Forensic Medicine
  • Instrumentation

Cite this

Sclerosing hemangioma of the lung in a young woman with cutaneous melanoma : The role of electron microscopy in preventing an erroneous diagnosis of metastasis. / Weeks, Douglas; Hammar, Samuel P.; Rader, Anne E.; Malott, Richelle; Mierau, Gary W.

In: Ultrastructural Pathology, Vol. 26, No. 4, 07.2002, p. 261-265.

Research output: Contribution to journalArticle

@article{f18cb59e80644e92b1da3a91f7001df9,
title = "Sclerosing hemangioma of the lung in a young woman with cutaneous melanoma: The role of electron microscopy in preventing an erroneous diagnosis of metastasis",
abstract = "A young woman with a melanoma of the left forearm was found to have a right lung mass. This was initially interpreted as metastatic melanoma on the basis of clinical, radiographic, and light microscopic features, together with positive staining of tumor cells with antibody HMB-45. Electron microscopic examination performed for confirmation of the diagnosis revealed no evidence of melanocytic differentiation. Instead, there were features suggestive of the alternative diagnosis of sclerosing hemangioma (SH). This diagnosis was confirmed with additional immunocytochemical stains. To the authors' knowledge this is the first report of HMB-45 positivity in SH. This case illustrates a potentially disastrous diagnostic pitfall in interpreting lung tumors in patients with melanoma, and the vital role of electron microscopy in resolving conflicting and/or misleading immunocytochemical results.",
keywords = "Electron microscopy, HMB-45, Melanoma, Sclerosing hemangioma",
author = "Douglas Weeks and Hammar, {Samuel P.} and Rader, {Anne E.} and Richelle Malott and Mierau, {Gary W.}",
year = "2002",
month = "7",
doi = "10.1080/01913120290104520",
language = "English (US)",
volume = "26",
pages = "261--265",
journal = "Ultrastructural Pathology",
issn = "0191-3123",
publisher = "Informa Healthcare",
number = "4",

}

TY - JOUR

T1 - Sclerosing hemangioma of the lung in a young woman with cutaneous melanoma

T2 - The role of electron microscopy in preventing an erroneous diagnosis of metastasis

AU - Weeks, Douglas

AU - Hammar, Samuel P.

AU - Rader, Anne E.

AU - Malott, Richelle

AU - Mierau, Gary W.

PY - 2002/7

Y1 - 2002/7

N2 - A young woman with a melanoma of the left forearm was found to have a right lung mass. This was initially interpreted as metastatic melanoma on the basis of clinical, radiographic, and light microscopic features, together with positive staining of tumor cells with antibody HMB-45. Electron microscopic examination performed for confirmation of the diagnosis revealed no evidence of melanocytic differentiation. Instead, there were features suggestive of the alternative diagnosis of sclerosing hemangioma (SH). This diagnosis was confirmed with additional immunocytochemical stains. To the authors' knowledge this is the first report of HMB-45 positivity in SH. This case illustrates a potentially disastrous diagnostic pitfall in interpreting lung tumors in patients with melanoma, and the vital role of electron microscopy in resolving conflicting and/or misleading immunocytochemical results.

AB - A young woman with a melanoma of the left forearm was found to have a right lung mass. This was initially interpreted as metastatic melanoma on the basis of clinical, radiographic, and light microscopic features, together with positive staining of tumor cells with antibody HMB-45. Electron microscopic examination performed for confirmation of the diagnosis revealed no evidence of melanocytic differentiation. Instead, there were features suggestive of the alternative diagnosis of sclerosing hemangioma (SH). This diagnosis was confirmed with additional immunocytochemical stains. To the authors' knowledge this is the first report of HMB-45 positivity in SH. This case illustrates a potentially disastrous diagnostic pitfall in interpreting lung tumors in patients with melanoma, and the vital role of electron microscopy in resolving conflicting and/or misleading immunocytochemical results.

KW - Electron microscopy

KW - HMB-45

KW - Melanoma

KW - Sclerosing hemangioma

UR - http://www.scopus.com/inward/record.url?scp=0036628975&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036628975&partnerID=8YFLogxK

U2 - 10.1080/01913120290104520

DO - 10.1080/01913120290104520

M3 - Article

VL - 26

SP - 261

EP - 265

JO - Ultrastructural Pathology

JF - Ultrastructural Pathology

SN - 0191-3123

IS - 4

ER -