Schwann cell tumors express characteristic patterns of CD44 splice variants

Lawrence (Larry) Sherman, Petra Skroch-Angel, Jurgen Moll, Karl Schwechheimer, Helmut Ponta, Peter Herrlich, Martin Hofmann

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Members of the CD44 family of cell surface hyaluronate-binding proteins have been implicated in cell migration, cell-matrix interactions and tumor progression. To determine whether these proteins might play a role in the normal functions of Schwann cells and in their tumorigenesis, we examined the patterns of CD44 expression in Schwann cells from rat peripheral nerve, rat Schwann cell tumor lines, and human schwannomas. Normal rat spinal nerves and primary Schwann cell cultures expressed standard CD44 (CD44s) but not alternatively spliced variant isoforms. In contrast, rat Schwann cell tumor lines expressed both CD44s and a number of variants, including proteins containing sequences encoded by exon v6. Furthermore, we found that these cell lines bind hyaluronate, and that their cell surface hyaluronate binding correlates with CD44 expression. All of the human schwannomas also expressed CD44 variants, especially epitopes encoded by exon v5, the border between v7 and v8, and v9-10. These data indicate that Schwann cells normally express CD44s, that Schwann cell tumors express both CD44s and particular variants of CD44, and that CD44s and possibly variants of CD44 are involved in hyaluronate recognition by Schwann cell tumors.

Original languageEnglish (US)
Pages (from-to)171-184
Number of pages14
JournalJournal of Neuro-Oncology
Volume26
Issue number3
DOIs
StatePublished - Dec 1995
Externally publishedYes

Fingerprint

Schwann Cells
Neoplasms
Neurilemmoma
Cell Line
Exons
Spinal Nerves
Primary Cell Culture
Peripheral Nerves
Cell Communication
Cell Movement
Epitopes
Carrier Proteins
Protein Isoforms
Carcinogenesis
Proteins

Keywords

  • CD44
  • hyaluronate
  • Schwann cells
  • schwannoma
  • sensory neurons

ASJC Scopus subject areas

  • Neuroscience(all)
  • Oncology
  • Clinical Neurology
  • Cancer Research

Cite this

Sherman, L. L., Skroch-Angel, P., Moll, J., Schwechheimer, K., Ponta, H., Herrlich, P., & Hofmann, M. (1995). Schwann cell tumors express characteristic patterns of CD44 splice variants. Journal of Neuro-Oncology, 26(3), 171-184. https://doi.org/10.1007/BF01052620

Schwann cell tumors express characteristic patterns of CD44 splice variants. / Sherman, Lawrence (Larry); Skroch-Angel, Petra; Moll, Jurgen; Schwechheimer, Karl; Ponta, Helmut; Herrlich, Peter; Hofmann, Martin.

In: Journal of Neuro-Oncology, Vol. 26, No. 3, 12.1995, p. 171-184.

Research output: Contribution to journalArticle

Sherman, LL, Skroch-Angel, P, Moll, J, Schwechheimer, K, Ponta, H, Herrlich, P & Hofmann, M 1995, 'Schwann cell tumors express characteristic patterns of CD44 splice variants', Journal of Neuro-Oncology, vol. 26, no. 3, pp. 171-184. https://doi.org/10.1007/BF01052620
Sherman LL, Skroch-Angel P, Moll J, Schwechheimer K, Ponta H, Herrlich P et al. Schwann cell tumors express characteristic patterns of CD44 splice variants. Journal of Neuro-Oncology. 1995 Dec;26(3):171-184. https://doi.org/10.1007/BF01052620
Sherman, Lawrence (Larry) ; Skroch-Angel, Petra ; Moll, Jurgen ; Schwechheimer, Karl ; Ponta, Helmut ; Herrlich, Peter ; Hofmann, Martin. / Schwann cell tumors express characteristic patterns of CD44 splice variants. In: Journal of Neuro-Oncology. 1995 ; Vol. 26, No. 3. pp. 171-184.
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