Schwanm cell abnormalities in 2, 5-hexanedione neuropathy

H. C. Powell, T. Koch, R. Garrett, P. W. Lampert

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Distinctive cytoplasmic alterations of Schwann cells were observed by electron microscopy in rats and mice with peripheral neuropathy induced by chronic exposure to 2,5-hexanedione. Pronounced enlargement of Schwann cells was due to accumulation of 100 Å cytoplasmic filaments and endoplasmic reticulum and was most often observed after 12-15 weeks exposure to 2,5-hexanedione. Examination of teased nerve fibres revealed segmental demyelination and remyelination involving axons of normal diameter as well as giant axons. The filament disorder induced by 2,5-hexanedione administration is not limited solely to axoplasmic contents. Possible mechanisms of demyelination are discussed and the changes are compared to those observed in human neuropathy for which 2,5-hexanedione appears to be the closest experimental model.

Original languageEnglish (US)
Pages (from-to)517-528
Number of pages12
JournalJournal of Neurocytology
Volume7
Issue number4
DOIs
StatePublished - Aug 1 1978

ASJC Scopus subject areas

  • Anatomy
  • Neuroscience(all)
  • Histology
  • Cell Biology

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    Powell, H. C., Koch, T., Garrett, R., & Lampert, P. W. (1978). Schwanm cell abnormalities in 2, 5-hexanedione neuropathy. Journal of Neurocytology, 7(4), 517-528. https://doi.org/10.1007/BF01173995