Schwanm cell abnormalities in 2, 5-hexanedione neuropathy

H. C. Powell, T. Koch, R. Garrett, P. W. Lampert

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Distinctive cytoplasmic alterations of Schwann cells were observed by electron microscopy in rats and mice with peripheral neuropathy induced by chronic exposure to 2,5-hexanedione. Pronounced enlargement of Schwann cells was due to accumulation of 100 Å cytoplasmic filaments and endoplasmic reticulum and was most often observed after 12-15 weeks exposure to 2,5-hexanedione. Examination of teased nerve fibres revealed segmental demyelination and remyelination involving axons of normal diameter as well as giant axons. The filament disorder induced by 2,5-hexanedione administration is not limited solely to axoplasmic contents. Possible mechanisms of demyelination are discussed and the changes are compared to those observed in human neuropathy for which 2,5-hexanedione appears to be the closest experimental model.

Original languageEnglish (US)
Pages (from-to)517-528
Number of pages12
JournalJournal of Neurocytology
Issue number4
StatePublished - Aug 1 1978

ASJC Scopus subject areas

  • Anatomy
  • Neuroscience(all)
  • Histology
  • Cell Biology


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