Scheme for efficient fiber-based CARS probe

Mihaela Balu, Gangjun Liu, Zhongping Chen, Bruce J. Tromberg, Eric O. Potma

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We demonstrate a fiber-based probe for maximum collection of the Coherent anti-Stokes Raman Scattering (CARS) signal in biological tissues. We discuss the design challenges including capturing the back-scattered forward generated CARS signal in the sample and the effects of fiber nonlinearities on the propagating pulses. Three different biological tissues were imaged in vitro in order to assess the performance of our fiberdelivered probe for CARS imaging, a tool which we consider an important advance towards label-free, in vivo probing of superficial tissues.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7569
DOIs
StatePublished - 2010
Externally publishedYes
EventMultiphoton Microscopy in the Biomedical Sciences X - San Francisco, CA, United States
Duration: Jan 24 2010Jan 26 2010

Other

OtherMultiphoton Microscopy in the Biomedical Sciences X
CountryUnited States
CitySan Francisco, CA
Period1/24/101/26/10

Fingerprint

Raman Spectrum Analysis
Raman scattering
Tissue
Raman spectra
fibers
Fibers
probes
Labels
nonlinearity
Imaging techniques
pulses

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Balu, M., Liu, G., Chen, Z., Tromberg, B. J., & Potma, E. O. (2010). Scheme for efficient fiber-based CARS probe. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7569). [75693A] https://doi.org/10.1117/12.855187

Scheme for efficient fiber-based CARS probe. / Balu, Mihaela; Liu, Gangjun; Chen, Zhongping; Tromberg, Bruce J.; Potma, Eric O.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7569 2010. 75693A.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Balu, M, Liu, G, Chen, Z, Tromberg, BJ & Potma, EO 2010, Scheme for efficient fiber-based CARS probe. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7569, 75693A, Multiphoton Microscopy in the Biomedical Sciences X, San Francisco, CA, United States, 1/24/10. https://doi.org/10.1117/12.855187
Balu M, Liu G, Chen Z, Tromberg BJ, Potma EO. Scheme for efficient fiber-based CARS probe. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7569. 2010. 75693A https://doi.org/10.1117/12.855187
Balu, Mihaela ; Liu, Gangjun ; Chen, Zhongping ; Tromberg, Bruce J. ; Potma, Eric O. / Scheme for efficient fiber-based CARS probe. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7569 2010.
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