Scarless Wound Healing

Alessandra L. Moore, Clement D. Marshall, Allison Nauta, Hermann P. Lorenz, Michael T. Longaker

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    Decades after the discovery of fetal scarless wound healing, therapeutic targets for reducing adult skin fibrosis remain few. Compounding the issue, the number of iatrogenic injuries and patients with multiple comorbidities is mounting, therefore increasing the likelihood of dysfunctional or pathologic wound healing. Also, there is overall growth in clinical expenditures on wound healing. Chapter 5 will contrast the adult and fetal wound healing mechanisms and review current therapeutic and experimental targets focused on reducing adult skin fibrosis and recapitulating the fetal wound healing environment. Through highlighting the differences between fetal and adult healing, scar reduction can be accomplished in the severely afflicted, such as those with contractures, keloids, or burns.

    Original languageEnglish (US)
    Title of host publicationPrinciples of Regenerative Medicine
    PublisherElsevier
    Pages65-92
    Number of pages28
    ISBN (Electronic)9780128098806
    ISBN (Print)9780128098936
    DOIs
    StatePublished - Jan 1 2018

    Keywords

    • Burn
    • Contracture
    • Fetal wound healing
    • Hypertrophic scars
    • Keloids
    • Scar reduction
    • Scarless
    • Skin regeneration
    • Skin wounds
    • Wound healing

    ASJC Scopus subject areas

    • Medicine(all)

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