Scanning laser polarimetry with enhanced corneal compensation and 00ptical coherence tomography in normal and glaucomatous eyes

Mitra Sehi, Stephen Ume, David S. Greenfield, Carolyn D. Quinn, David Huang, Rohit Varma, Vikas Chopra, Brian Francis, Don Minckler, Ou Tan, Scott D. Smith, Edward J. Rockwood, Joel S. Schuman, Robert Noecker, Zvia Eliash, Hiroshi Ishikawa, Gadi Wollstein, Larry Kagemann

Research output: Contribution to journalArticle

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Abstract

PURPOSE. To examine the association between scanning laser polarimetry (SLP), using enhanced (ECC) and variable corneal compensation (VCC) with optical coherence tomography (OCT), and to compare their discriminating ability in the diagnosis of glaucoma. METHODS. Normal and glaucomatous eyes enrolled from four clinical sites underwent complete examination, automated perimetry, SLP-ECC, SLP-VCC, and OCT. Eyes were characterized in two groups based on the typical scan score (TSS): Normal birefringence pattern (NBP) was defined as a TSS of 80 to 100 and abnormal birefringence pattern (ABP) as TSS ≤ 79. For each of the six SLP parameters and five OCT parameters the areas under the receiver operating characteristic curve (AUROCs) were calculated to compare the discriminating ability of each imaging modality, to differentiate between normal and glaucomatous eyes. RESULTS. Ninety-five normal volunteers and 63 patients with glaucoma were enrolled. Average visual field mean deviation was -4.2 ± 4.3 dB in the glaucoma group. In eyes with NBP, SLP-ECC had significantly (all P ≤ 0.001) greater correlation with OCT average, superior, and inferior retinal nerve fiber layer (RNFL; r = 0.79, 0.67, 0.74) compared with SLP-VCC (r = 0.71, 0.43, 0.37). In eyes with ABP, SLP-ECC had a significantly greater (all P ≤ 0.001) correlation with OCT average, superior, and inferior RNFL (r = 0.75, 0.73, 0.83) compared with SLP-VCC (r = 0.51, 0.22, 0.18). The AUROC for OCT inferior average thickness (0.91) was similar (P = 0.26) to the TSNIT (temporal, superior, nasal, inferior, temporal) average obtained using SLP-ECC (0.87) and significantly (P = 0.02) greater than SLP-VCC (0.81). CONCLUSIONS. Compared with SLP-VCC, SLP-ECC has significantly stronger correlations with OCT and may improve the discriminating ability for early glaucoma diagnosis.

Original languageEnglish (US)
Pages (from-to)2099-2104
Number of pages6
JournalInvestigative Ophthalmology and Visual Science
Volume48
Issue number5
DOIs
StatePublished - May 2007
Externally publishedYes

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Scanning Laser Polarimetry
Tomography
Optical Coherence Tomography
Birefringence
Glaucoma
Aptitude
ROC Curve
Visual Field Tests
Visual Fields
Nerve Fibers
Nose

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Scanning laser polarimetry with enhanced corneal compensation and 00ptical coherence tomography in normal and glaucomatous eyes. / Sehi, Mitra; Ume, Stephen; Greenfield, David S.; Quinn, Carolyn D.; Huang, David; Varma, Rohit; Chopra, Vikas; Francis, Brian; Minckler, Don; Tan, Ou; Smith, Scott D.; Rockwood, Edward J.; Schuman, Joel S.; Noecker, Robert; Eliash, Zvia; Ishikawa, Hiroshi; Wollstein, Gadi; Kagemann, Larry.

In: Investigative Ophthalmology and Visual Science, Vol. 48, No. 5, 05.2007, p. 2099-2104.

Research output: Contribution to journalArticle

Sehi, M, Ume, S, Greenfield, DS, Quinn, CD, Huang, D, Varma, R, Chopra, V, Francis, B, Minckler, D, Tan, O, Smith, SD, Rockwood, EJ, Schuman, JS, Noecker, R, Eliash, Z, Ishikawa, H, Wollstein, G & Kagemann, L 2007, 'Scanning laser polarimetry with enhanced corneal compensation and 00ptical coherence tomography in normal and glaucomatous eyes', Investigative Ophthalmology and Visual Science, vol. 48, no. 5, pp. 2099-2104. https://doi.org/10.1167/iovs.06-1087
Sehi, Mitra ; Ume, Stephen ; Greenfield, David S. ; Quinn, Carolyn D. ; Huang, David ; Varma, Rohit ; Chopra, Vikas ; Francis, Brian ; Minckler, Don ; Tan, Ou ; Smith, Scott D. ; Rockwood, Edward J. ; Schuman, Joel S. ; Noecker, Robert ; Eliash, Zvia ; Ishikawa, Hiroshi ; Wollstein, Gadi ; Kagemann, Larry. / Scanning laser polarimetry with enhanced corneal compensation and 00ptical coherence tomography in normal and glaucomatous eyes. In: Investigative Ophthalmology and Visual Science. 2007 ; Vol. 48, No. 5. pp. 2099-2104.
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T1 - Scanning laser polarimetry with enhanced corneal compensation and 00ptical coherence tomography in normal and glaucomatous eyes

AU - Sehi, Mitra

AU - Ume, Stephen

AU - Greenfield, David S.

AU - Quinn, Carolyn D.

AU - Huang, David

AU - Varma, Rohit

AU - Chopra, Vikas

AU - Francis, Brian

AU - Minckler, Don

AU - Tan, Ou

AU - Smith, Scott D.

AU - Rockwood, Edward J.

AU - Schuman, Joel S.

AU - Noecker, Robert

AU - Eliash, Zvia

AU - Ishikawa, Hiroshi

AU - Wollstein, Gadi

AU - Kagemann, Larry

PY - 2007/5

Y1 - 2007/5

N2 - PURPOSE. To examine the association between scanning laser polarimetry (SLP), using enhanced (ECC) and variable corneal compensation (VCC) with optical coherence tomography (OCT), and to compare their discriminating ability in the diagnosis of glaucoma. METHODS. Normal and glaucomatous eyes enrolled from four clinical sites underwent complete examination, automated perimetry, SLP-ECC, SLP-VCC, and OCT. Eyes were characterized in two groups based on the typical scan score (TSS): Normal birefringence pattern (NBP) was defined as a TSS of 80 to 100 and abnormal birefringence pattern (ABP) as TSS ≤ 79. For each of the six SLP parameters and five OCT parameters the areas under the receiver operating characteristic curve (AUROCs) were calculated to compare the discriminating ability of each imaging modality, to differentiate between normal and glaucomatous eyes. RESULTS. Ninety-five normal volunteers and 63 patients with glaucoma were enrolled. Average visual field mean deviation was -4.2 ± 4.3 dB in the glaucoma group. In eyes with NBP, SLP-ECC had significantly (all P ≤ 0.001) greater correlation with OCT average, superior, and inferior retinal nerve fiber layer (RNFL; r = 0.79, 0.67, 0.74) compared with SLP-VCC (r = 0.71, 0.43, 0.37). In eyes with ABP, SLP-ECC had a significantly greater (all P ≤ 0.001) correlation with OCT average, superior, and inferior RNFL (r = 0.75, 0.73, 0.83) compared with SLP-VCC (r = 0.51, 0.22, 0.18). The AUROC for OCT inferior average thickness (0.91) was similar (P = 0.26) to the TSNIT (temporal, superior, nasal, inferior, temporal) average obtained using SLP-ECC (0.87) and significantly (P = 0.02) greater than SLP-VCC (0.81). CONCLUSIONS. Compared with SLP-VCC, SLP-ECC has significantly stronger correlations with OCT and may improve the discriminating ability for early glaucoma diagnosis.

AB - PURPOSE. To examine the association between scanning laser polarimetry (SLP), using enhanced (ECC) and variable corneal compensation (VCC) with optical coherence tomography (OCT), and to compare their discriminating ability in the diagnosis of glaucoma. METHODS. Normal and glaucomatous eyes enrolled from four clinical sites underwent complete examination, automated perimetry, SLP-ECC, SLP-VCC, and OCT. Eyes were characterized in two groups based on the typical scan score (TSS): Normal birefringence pattern (NBP) was defined as a TSS of 80 to 100 and abnormal birefringence pattern (ABP) as TSS ≤ 79. For each of the six SLP parameters and five OCT parameters the areas under the receiver operating characteristic curve (AUROCs) were calculated to compare the discriminating ability of each imaging modality, to differentiate between normal and glaucomatous eyes. RESULTS. Ninety-five normal volunteers and 63 patients with glaucoma were enrolled. Average visual field mean deviation was -4.2 ± 4.3 dB in the glaucoma group. In eyes with NBP, SLP-ECC had significantly (all P ≤ 0.001) greater correlation with OCT average, superior, and inferior retinal nerve fiber layer (RNFL; r = 0.79, 0.67, 0.74) compared with SLP-VCC (r = 0.71, 0.43, 0.37). In eyes with ABP, SLP-ECC had a significantly greater (all P ≤ 0.001) correlation with OCT average, superior, and inferior RNFL (r = 0.75, 0.73, 0.83) compared with SLP-VCC (r = 0.51, 0.22, 0.18). The AUROC for OCT inferior average thickness (0.91) was similar (P = 0.26) to the TSNIT (temporal, superior, nasal, inferior, temporal) average obtained using SLP-ECC (0.87) and significantly (P = 0.02) greater than SLP-VCC (0.81). CONCLUSIONS. Compared with SLP-VCC, SLP-ECC has significantly stronger correlations with OCT and may improve the discriminating ability for early glaucoma diagnosis.

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