Sarcopenia is not associated with morbidity, mortality, or recurrence after esophagectomy for cancer

Steve R. Siegal, James Dolan, Elizabeth N. Dewey, Alexander Guimaraes, Brandon Tieu, Paul Schipper, John Hunter

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Sarcopenia is associated with increased morbidity and mortality in hepatic, pancreatic and colorectal cancer. We examined the effect of sarcopenia on morbidity, mortality, and recurrence after resection for esophageal cancer. Methods: Retrospective review of consecutive esophagectomies from 2010 to 2015. Computed tomography studies were analyzed for sarcopenia. Morbidity was analyzed using Fischer's test and survival data with Kaplan Meier curves. Results: The sarcopenic group (n = 127) had lower BMI, later stage disease, and higher incidence of neoadjuvant radiation than those without sarcopenia (n = 46). There were no differences in morbidity or mortality between the groups (p = .75 and p = .31, respectively). Mean length of stay was similar (p = .70). Disease free and overall survival were similar (p = .20 and p = .39, respectively). Conclusion: There is no association between sarcopenia and increased morbidity, mortality and disease-free survival in patients undergoing esophagectomy for cancer. Sarcopenia in esophageal cancer may not portend worse outcomes that have been reported in other solid tumors.

Original languageEnglish (US)
JournalAmerican Journal of Surgery
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Sarcopenia
Esophagectomy
Morbidity
Recurrence
Mortality
Neoplasms
Esophageal Neoplasms
Disease-Free Survival
Liver Neoplasms
Pancreatic Neoplasms
Colorectal Neoplasms
Length of Stay
Tomography
Radiation
Survival
Incidence

Keywords

  • Esophageal cancer
  • Esophagectomy
  • Outcomes
  • Recurrence
  • Sarcopenia

ASJC Scopus subject areas

  • Surgery

Cite this

@article{e0df97dc613941e39c4de7a4991f5e72,
title = "Sarcopenia is not associated with morbidity, mortality, or recurrence after esophagectomy for cancer",
abstract = "Background: Sarcopenia is associated with increased morbidity and mortality in hepatic, pancreatic and colorectal cancer. We examined the effect of sarcopenia on morbidity, mortality, and recurrence after resection for esophageal cancer. Methods: Retrospective review of consecutive esophagectomies from 2010 to 2015. Computed tomography studies were analyzed for sarcopenia. Morbidity was analyzed using Fischer's test and survival data with Kaplan Meier curves. Results: The sarcopenic group (n = 127) had lower BMI, later stage disease, and higher incidence of neoadjuvant radiation than those without sarcopenia (n = 46). There were no differences in morbidity or mortality between the groups (p = .75 and p = .31, respectively). Mean length of stay was similar (p = .70). Disease free and overall survival were similar (p = .20 and p = .39, respectively). Conclusion: There is no association between sarcopenia and increased morbidity, mortality and disease-free survival in patients undergoing esophagectomy for cancer. Sarcopenia in esophageal cancer may not portend worse outcomes that have been reported in other solid tumors.",
keywords = "Esophageal cancer, Esophagectomy, Outcomes, Recurrence, Sarcopenia",
author = "Siegal, {Steve R.} and James Dolan and Dewey, {Elizabeth N.} and Alexander Guimaraes and Brandon Tieu and Paul Schipper and John Hunter",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.amjsurg.2017.12.017",
language = "English (US)",
journal = "American Journal of Surgery",
issn = "0002-9610",
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TY - JOUR

T1 - Sarcopenia is not associated with morbidity, mortality, or recurrence after esophagectomy for cancer

AU - Siegal, Steve R.

AU - Dolan, James

AU - Dewey, Elizabeth N.

AU - Guimaraes, Alexander

AU - Tieu, Brandon

AU - Schipper, Paul

AU - Hunter, John

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Sarcopenia is associated with increased morbidity and mortality in hepatic, pancreatic and colorectal cancer. We examined the effect of sarcopenia on morbidity, mortality, and recurrence after resection for esophageal cancer. Methods: Retrospective review of consecutive esophagectomies from 2010 to 2015. Computed tomography studies were analyzed for sarcopenia. Morbidity was analyzed using Fischer's test and survival data with Kaplan Meier curves. Results: The sarcopenic group (n = 127) had lower BMI, later stage disease, and higher incidence of neoadjuvant radiation than those without sarcopenia (n = 46). There were no differences in morbidity or mortality between the groups (p = .75 and p = .31, respectively). Mean length of stay was similar (p = .70). Disease free and overall survival were similar (p = .20 and p = .39, respectively). Conclusion: There is no association between sarcopenia and increased morbidity, mortality and disease-free survival in patients undergoing esophagectomy for cancer. Sarcopenia in esophageal cancer may not portend worse outcomes that have been reported in other solid tumors.

AB - Background: Sarcopenia is associated with increased morbidity and mortality in hepatic, pancreatic and colorectal cancer. We examined the effect of sarcopenia on morbidity, mortality, and recurrence after resection for esophageal cancer. Methods: Retrospective review of consecutive esophagectomies from 2010 to 2015. Computed tomography studies were analyzed for sarcopenia. Morbidity was analyzed using Fischer's test and survival data with Kaplan Meier curves. Results: The sarcopenic group (n = 127) had lower BMI, later stage disease, and higher incidence of neoadjuvant radiation than those without sarcopenia (n = 46). There were no differences in morbidity or mortality between the groups (p = .75 and p = .31, respectively). Mean length of stay was similar (p = .70). Disease free and overall survival were similar (p = .20 and p = .39, respectively). Conclusion: There is no association between sarcopenia and increased morbidity, mortality and disease-free survival in patients undergoing esophagectomy for cancer. Sarcopenia in esophageal cancer may not portend worse outcomes that have been reported in other solid tumors.

KW - Esophageal cancer

KW - Esophagectomy

KW - Outcomes

KW - Recurrence

KW - Sarcopenia

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