Sarcopenia is not associated with morbidity, mortality, or recurrence after esophagectomy for cancer

Steve R. Siegal, James Dolan, Elizabeth N. Dewey, Alexander R. Guimaraes, Brandon Tieu, Paul H. Schipper, John G. Hunter

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Background: Sarcopenia is associated with increased morbidity and mortality in hepatic, pancreatic and colorectal cancer. We examined the effect of sarcopenia on morbidity, mortality, and recurrence after resection for esophageal cancer. Methods: Retrospective review of consecutive esophagectomies from 2010 to 2015. Computed tomography studies were analyzed for sarcopenia. Morbidity was analyzed using Fischer's test and survival data with Kaplan Meier curves. Results: The sarcopenic group (n = 127) had lower BMI, later stage disease, and higher incidence of neoadjuvant radiation than those without sarcopenia (n = 46). There were no differences in morbidity or mortality between the groups (p =.75 and p =.31, respectively). Mean length of stay was similar (p =.70). Disease free and overall survival were similar (p =.20 and p =.39, respectively). Conclusion: There is no association between sarcopenia and increased morbidity, mortality and disease-free survival in patients undergoing esophagectomy for cancer. Sarcopenia in esophageal cancer may not portend worse outcomes that have been reported in other solid tumors.

Original languageEnglish (US)
Pages (from-to)813-817
Number of pages5
JournalAmerican journal of surgery
Issue number5
StatePublished - May 2018


  • Esophageal cancer
  • Esophagectomy
  • Outcomes
  • Recurrence
  • Sarcopenia

ASJC Scopus subject areas

  • Surgery


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