TY - JOUR
T1 - Salmonella typhimurium phoP virulence gene is a transcriptional regulator
AU - Groisman, E. A.
AU - Chiao, E.
AU - Lipps, C. J.
AU - Heffron, F.
PY - 1989
Y1 - 1989
N2 - Salmonella typhimurium is a facultative intracellular pathogen capable of surviving within host pathocytic cells. Salmonella strains carrying phoP mutations are avirulent, unable to survive in macrophages, and extremely sensitive to peptides having antimicrobial activity such as the host-derived defensins. We present here the DNA sequence of the phoP gene and show that the deduced amino acid sequence of phoP has extensive homology with the Escherichia coli transcriptional regulators PhoB and OmpR, which control the expression of loci in response to different environmental stimuli. The psiD locus, which is regulated by phosphate availability, was found to be under the control of the phoP gene product. Sequences homologous to phoP were found in several Gram-negative species and in the yeast Saccharomyces cerevisiae.
AB - Salmonella typhimurium is a facultative intracellular pathogen capable of surviving within host pathocytic cells. Salmonella strains carrying phoP mutations are avirulent, unable to survive in macrophages, and extremely sensitive to peptides having antimicrobial activity such as the host-derived defensins. We present here the DNA sequence of the phoP gene and show that the deduced amino acid sequence of phoP has extensive homology with the Escherichia coli transcriptional regulators PhoB and OmpR, which control the expression of loci in response to different environmental stimuli. The psiD locus, which is regulated by phosphate availability, was found to be under the control of the phoP gene product. Sequences homologous to phoP were found in several Gram-negative species and in the yeast Saccharomyces cerevisiae.
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U2 - 10.1073/pnas.86.18.7077
DO - 10.1073/pnas.86.18.7077
M3 - Article
C2 - 2674945
AN - SCOPUS:0343575172
SN - 0027-8424
VL - 86
SP - 7077
EP - 7081
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 18
ER -