Salivary proteomics in bisphosphonate-related osteonecrosis of the jaw

V. Thumbigere-Math, B. S. Michalowicz, E. P. de Jong, T. J. Griffin, D. L. Basi, Pamela Hughes, M. L. Tsai, K. K. Swenson, L. Rockwell, R. Gopalakrishnan

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: The objective of this study was to identify differentially expressed salivary proteins in bisphosphonate-related osteonecrosis of the jaw (BRONJ) patients that could serve as biomarkers for BRONJ diagnosis. Subjects and Methods: Whole saliva obtained from 20 BRONJ patients and 20 controls were pooled within groups. The samples were analyzed using iTRAQ-labeled two-dimensional liquid chromatography-tandem mass spectrometry. Results: Overall, 1340 proteins were identified. Of these, biomarker candidates were selected based on P-value (

Original languageEnglish (US)
Pages (from-to)46-56
Number of pages11
JournalOral Diseases
Volume21
Issue number1
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

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Bisphosphonate-Associated Osteonecrosis of the Jaw
Proteomics
Biomarkers
Salivary Proteins and Peptides
Tandem Mass Spectrometry
Saliva
Liquid Chromatography
Proteins

Keywords

  • Biological markers
  • Biomarkers
  • Bisphosphonate
  • Bisphosphonate-related osteonecrosis of the jaw
  • Osteonecrosis of the jaw
  • Proteomics
  • Saliva

ASJC Scopus subject areas

  • Dentistry(all)
  • Otorhinolaryngology

Cite this

Thumbigere-Math, V., Michalowicz, B. S., de Jong, E. P., Griffin, T. J., Basi, D. L., Hughes, P., ... Gopalakrishnan, R. (2015). Salivary proteomics in bisphosphonate-related osteonecrosis of the jaw. Oral Diseases, 21(1), 46-56. https://doi.org/10.1111/odi.12204

Salivary proteomics in bisphosphonate-related osteonecrosis of the jaw. / Thumbigere-Math, V.; Michalowicz, B. S.; de Jong, E. P.; Griffin, T. J.; Basi, D. L.; Hughes, Pamela; Tsai, M. L.; Swenson, K. K.; Rockwell, L.; Gopalakrishnan, R.

In: Oral Diseases, Vol. 21, No. 1, 01.01.2015, p. 46-56.

Research output: Contribution to journalArticle

Thumbigere-Math, V, Michalowicz, BS, de Jong, EP, Griffin, TJ, Basi, DL, Hughes, P, Tsai, ML, Swenson, KK, Rockwell, L & Gopalakrishnan, R 2015, 'Salivary proteomics in bisphosphonate-related osteonecrosis of the jaw', Oral Diseases, vol. 21, no. 1, pp. 46-56. https://doi.org/10.1111/odi.12204
Thumbigere-Math V, Michalowicz BS, de Jong EP, Griffin TJ, Basi DL, Hughes P et al. Salivary proteomics in bisphosphonate-related osteonecrosis of the jaw. Oral Diseases. 2015 Jan 1;21(1):46-56. https://doi.org/10.1111/odi.12204
Thumbigere-Math, V. ; Michalowicz, B. S. ; de Jong, E. P. ; Griffin, T. J. ; Basi, D. L. ; Hughes, Pamela ; Tsai, M. L. ; Swenson, K. K. ; Rockwell, L. ; Gopalakrishnan, R. / Salivary proteomics in bisphosphonate-related osteonecrosis of the jaw. In: Oral Diseases. 2015 ; Vol. 21, No. 1. pp. 46-56.
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