Salivary cortisol awakening response in mild Alzheimer disease, caregivers, and noncaregivers

Helana Wahbeh, Shirley S. Kishiyama, Daniel Zajdel, Barry Oken

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Alterations in the hypothalamic-pituitary-adrenal axis have been noted in people with Alzheimer disease (AD) and in the people caring for them. In a case-control study, we assessed whether the cortisol response at awakening and diurnal cortisol would reflect these changes. AD patients, their caregivers, and healthy senior noncaregivers collected saliva within 5 minutes of waking, 30 minutes after waking, before lunch, 1 hour after lunch, and at 11 pm or when getting ready for bed. They also completed a Perceived Stress Scale. Total cortisol for the day after adjusting for antidepressant use revealed a group effect [F(2,39) = 12.49, P <0.0001], with mild AD patients and caregivers having higher cortisol values. Unlike the noncaregivers (t = -1.15, df = 14, P > 0.27), both cortisol values of the AD caregivers (t = -2.96, df = 16, P <0.03) and the AD patients' (t = -2.5, df=14, P

Original languageEnglish (US)
Pages (from-to)181-183
Number of pages3
JournalAlzheimer Disease and Associated Disorders
Volume22
Issue number2
DOIs
StatePublished - Apr 2008

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Caregivers
Hydrocortisone
Alzheimer Disease
Lunch
Saliva
Antidepressive Agents
Case-Control Studies

Keywords

  • Alzheimer disease
  • Awakening cortisol
  • Stress

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Gerontology
  • Clinical Psychology
  • Neuroscience(all)

Cite this

Salivary cortisol awakening response in mild Alzheimer disease, caregivers, and noncaregivers. / Wahbeh, Helana; Kishiyama, Shirley S.; Zajdel, Daniel; Oken, Barry.

In: Alzheimer Disease and Associated Disorders, Vol. 22, No. 2, 04.2008, p. 181-183.

Research output: Contribution to journalArticle

Wahbeh, Helana ; Kishiyama, Shirley S. ; Zajdel, Daniel ; Oken, Barry. / Salivary cortisol awakening response in mild Alzheimer disease, caregivers, and noncaregivers. In: Alzheimer Disease and Associated Disorders. 2008 ; Vol. 22, No. 2. pp. 181-183.
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