Abstract
Alterations in the hypothalamic-pituitary-adrenal axis have been noted in people with Alzheimer disease (AD) and in the people caring for them. In a case-control study, we assessed whether the cortisol response at awakening and diurnal cortisol would reflect these changes. AD patients, their caregivers, and healthy senior noncaregivers collected saliva within 5 minutes of waking, 30 minutes after waking, before lunch, 1 hour after lunch, and at 11 pm or when getting ready for bed. They also completed a Perceived Stress Scale. Total cortisol for the day after adjusting for antidepressant use revealed a group effect [F(2,39) = 12.49, P <0.0001], with mild AD patients and caregivers having higher cortisol values. Unlike the noncaregivers (t = -1.15, df = 14, P > 0.27), both cortisol values of the AD caregivers (t = -2.96, df = 16, P <0.03) and the AD patients' (t = -2.5, df=14, P
| Original language | English (US) |
|---|---|
| Pages (from-to) | 181-183 |
| Number of pages | 3 |
| Journal | Alzheimer Disease and Associated Disorders |
| Volume | 22 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 2008 |
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Keywords
- Alzheimer disease
- Awakening cortisol
- Stress
ASJC Scopus subject areas
- Geriatrics and Gerontology
- Psychiatry and Mental health
- Gerontology
- Clinical Psychology
- Neuroscience(all)
Cite this
Salivary cortisol awakening response in mild Alzheimer disease, caregivers, and noncaregivers. / Wahbeh, Helana; Kishiyama, Shirley S.; Zajdel, Daniel; Oken, Barry.
In: Alzheimer Disease and Associated Disorders, Vol. 22, No. 2, 04.2008, p. 181-183.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Salivary cortisol awakening response in mild Alzheimer disease, caregivers, and noncaregivers
AU - Wahbeh, Helana
AU - Kishiyama, Shirley S.
AU - Zajdel, Daniel
AU - Oken, Barry
PY - 2008/4
Y1 - 2008/4
N2 - Alterations in the hypothalamic-pituitary-adrenal axis have been noted in people with Alzheimer disease (AD) and in the people caring for them. In a case-control study, we assessed whether the cortisol response at awakening and diurnal cortisol would reflect these changes. AD patients, their caregivers, and healthy senior noncaregivers collected saliva within 5 minutes of waking, 30 minutes after waking, before lunch, 1 hour after lunch, and at 11 pm or when getting ready for bed. They also completed a Perceived Stress Scale. Total cortisol for the day after adjusting for antidepressant use revealed a group effect [F(2,39) = 12.49, P <0.0001], with mild AD patients and caregivers having higher cortisol values. Unlike the noncaregivers (t = -1.15, df = 14, P > 0.27), both cortisol values of the AD caregivers (t = -2.96, df = 16, P <0.03) and the AD patients' (t = -2.5, df=14, P
AB - Alterations in the hypothalamic-pituitary-adrenal axis have been noted in people with Alzheimer disease (AD) and in the people caring for them. In a case-control study, we assessed whether the cortisol response at awakening and diurnal cortisol would reflect these changes. AD patients, their caregivers, and healthy senior noncaregivers collected saliva within 5 minutes of waking, 30 minutes after waking, before lunch, 1 hour after lunch, and at 11 pm or when getting ready for bed. They also completed a Perceived Stress Scale. Total cortisol for the day after adjusting for antidepressant use revealed a group effect [F(2,39) = 12.49, P <0.0001], with mild AD patients and caregivers having higher cortisol values. Unlike the noncaregivers (t = -1.15, df = 14, P > 0.27), both cortisol values of the AD caregivers (t = -2.96, df = 16, P <0.03) and the AD patients' (t = -2.5, df=14, P
KW - Alzheimer disease
KW - Awakening cortisol
KW - Stress
UR - http://www.scopus.com/inward/record.url?scp=46249111929&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=46249111929&partnerID=8YFLogxK
U2 - 10.1097/WAD.0b013e31815a9dff
DO - 10.1097/WAD.0b013e31815a9dff
M3 - Article
C2 - 18525292
AN - SCOPUS:46249111929
VL - 22
SP - 181
EP - 183
JO - Alzheimer Disease and Associated Disorders
JF - Alzheimer Disease and Associated Disorders
SN - 0893-0341
IS - 2
ER -