Safety, efficacy, and patient acceptability of lidocaine hydrochloride ophthalmic gel as a topical ocular anesthetic for use in ophthalmic procedures

Michael A. Page, Frederick W. Fraunfelder

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Purpose: To review the current literature on safety, efficacy, and measures of surgeon and patient satisfaction with lidocaine hydrochloride gel as a tool for ocular anesthesia. Methods: Pubmed search using keywords "lidocaine gel," "ophthalmic," and "surgery" and compiling cross-references. Twenty-six total references were reviewed, including 15 prospective randomized controlled trials (RCTs, total N = 933, average N = 62), 6 nonrandomized prospective studies (total N = 234, average N = 39), 2 animal studies, 1 microbiologic study, and 2 letters to the editor. Results: The RCTs and nonrandomized prospective studies evaluated a number of measures including timing of onset of anesthesia, duration of anesthesia, intraoperative and postoperative pain, need for additional anesthetic applications, intracameral lidocaine levels, and adverse effects. Control groups received topical drops, subconjunctival anesthetic, retrobulbar anesthetic, or sham gel. Lidocaine gel was shown to be at least as effective for pain control as alternative therapies in all studies, with longer duration of action than topical drops. Patient and surgeon satisfaction were high, and adverse effects were rare and comparable to those for anesthetic drop formulations. Surgical settings included cataract, pterygium, trabeculectomy, strabismus, intravitreal injection, vitrectomy, and penetrating keratoplasty. Conclusions: Lidocaine gel is a safe, effective, and potentially underutilized tool for ophthalmic surgery.

Original languageEnglish (US)
Pages (from-to)601-609
Number of pages9
JournalClinical Ophthalmology
Volume3
Issue number1
StatePublished - 2009

Fingerprint

Patient Safety
Lidocaine
Local Anesthetics
Gels
Anesthetics
Anesthesia
Patient Satisfaction
Prospective Studies
Pterygium
Penetrating Keratoplasty
Intravitreal Injections
Trabeculectomy
Strabismus
Vitrectomy
Complementary Therapies
Postoperative Pain
PubMed
Cataract
Randomized Controlled Trials
Safety

Keywords

  • Anesthetic
  • Gel
  • Lidocaine
  • Ocular
  • Ophthalmic
  • Topical

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Safety, efficacy, and patient acceptability of lidocaine hydrochloride ophthalmic gel as a topical ocular anesthetic for use in ophthalmic procedures. / Page, Michael A.; Fraunfelder, Frederick W.

In: Clinical Ophthalmology, Vol. 3, No. 1, 2009, p. 601-609.

Research output: Contribution to journalArticle

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