Safety and efficacy of upfront plerixafor + G-CSF versus placebo + G-CSF for mobilization of CD34+ hematopoietic progenitor cells in patients ≥60 and

Ivana N. Micallef, Patrick J. Stiff, Edward A. Stadtmauer, Brian J. Bolwell, Auayporn P. Nademanee, Richard Maziarz, Angela M. Partisano, Sachin Marulkar, John F. Dipersio

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The efficacy and safety of plerixafor + G-CSF in enhancing hematopoietic stem cell mobilization and collection has been demonstrated in two phase III studies involving patients with NHL or MM. In these pivotal studies, plerixafor + G-CSF significantly increased the proportion of patients achieving target stem cell yields, compared to placebo + G-CSF. In this analysis, we compare the efficacy and safety of plerixafor + G-CSF versus placebo + G-CSF in patients enrolled in the two phase III studies, stratified by age: ≥60 years of age and

Original languageEnglish (US)
Pages (from-to)1017-1023
Number of pages7
JournalAmerican Journal of Hematology
Volume88
Issue number12
DOIs
StatePublished - Dec 2013

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Granulocyte Colony-Stimulating Factor
Hematopoietic Stem Cells
Placebos
Safety
Hematopoietic Stem Cell Mobilization
Stem Cells
JM 3100

ASJC Scopus subject areas

  • Hematology

Cite this

Safety and efficacy of upfront plerixafor + G-CSF versus placebo + G-CSF for mobilization of CD34+ hematopoietic progenitor cells in patients ≥60 and . / Micallef, Ivana N.; Stiff, Patrick J.; Stadtmauer, Edward A.; Bolwell, Brian J.; Nademanee, Auayporn P.; Maziarz, Richard; Partisano, Angela M.; Marulkar, Sachin; Dipersio, John F.

In: American Journal of Hematology, Vol. 88, No. 12, 12.2013, p. 1017-1023.

Research output: Contribution to journalArticle

Micallef, IN, Stiff, PJ, Stadtmauer, EA, Bolwell, BJ, Nademanee, AP, Maziarz, R, Partisano, AM, Marulkar, S & Dipersio, JF 2013, 'Safety and efficacy of upfront plerixafor + G-CSF versus placebo + G-CSF for mobilization of CD34+ hematopoietic progenitor cells in patients ≥60 and ', American Journal of Hematology, vol. 88, no. 12, pp. 1017-1023. https://doi.org/10.1002/ajh.23561
Micallef, Ivana N. ; Stiff, Patrick J. ; Stadtmauer, Edward A. ; Bolwell, Brian J. ; Nademanee, Auayporn P. ; Maziarz, Richard ; Partisano, Angela M. ; Marulkar, Sachin ; Dipersio, John F. / Safety and efficacy of upfront plerixafor + G-CSF versus placebo + G-CSF for mobilization of CD34+ hematopoietic progenitor cells in patients ≥60 and . In: American Journal of Hematology. 2013 ; Vol. 88, No. 12. pp. 1017-1023.
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