Safety and efficacy of mechanical embolectomy in acute ischemic stroke

Results of the MERCI trial

Wade S. Smith, Gene Sung, Sidney Starkman, Jeffrey L. Saver, Chelsea S. Kidwell, Y. Pierre Gobin, Helmi Lutsep, Gary Nesbit, Thomas Grobelny, Marilyn M. Rymer, Isaac E. Silverman, Randall T. Higashida, Ronald F. Budzik, Michael P. Marks

Research output: Contribution to journalArticle

1056 Citations (Scopus)

Abstract

Background and Purpose - The only Food and Drug Administration (FDA)-approved treatment for acute ischemic stroke is tissue plasminogen activator (tPA) given intravenously within 3 hours of symptom onset. An alternative strategy for opening intracranial vessels during stroke is mechanical embolectomy, especially for patients ineligible for intravenous tPA. Methods - We investigated the safety and efficacy of a novel embolectomy device (Merci Retriever) to open occluded intracranial large vessels within 8 hours of the onset of stroke symptoms in a prospective, nonrandomized, multicenter trial. All patients were ineligible for intravenous tPA. Primary outcomes were recanalization and safety, and secondary outcomes were neurological outcome at 90 days in recanalized versus nonrecanalized patients. Results - Recanalization was achieved in 46% (69/151) of patients on intention to treat analysis, and in 48% (68/141) of patients in whom the device was deployed. This rate is significantly higher than that expected using an historical control of 18% (P

Original languageEnglish (US)
Pages (from-to)1432-1438
Number of pages7
JournalStroke
Volume36
Issue number7
DOIs
StatePublished - Jul 2005

Fingerprint

Embolectomy
Stroke
Safety
Tissue Plasminogen Activator
Equipment and Supplies
Intention to Treat Analysis
United States Food and Drug Administration
Multicenter Studies

Keywords

  • Angiography
  • Embolectomy
  • Embolism
  • Ischemia
  • Reperfusion
  • Stroke, acute
  • Thrombectomy
  • Treatment outcome

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Smith, W. S., Sung, G., Starkman, S., Saver, J. L., Kidwell, C. S., Gobin, Y. P., ... Marks, M. P. (2005). Safety and efficacy of mechanical embolectomy in acute ischemic stroke: Results of the MERCI trial. Stroke, 36(7), 1432-1438. https://doi.org/10.1161/01.STR.0000171066.25248.1d

Safety and efficacy of mechanical embolectomy in acute ischemic stroke : Results of the MERCI trial. / Smith, Wade S.; Sung, Gene; Starkman, Sidney; Saver, Jeffrey L.; Kidwell, Chelsea S.; Gobin, Y. Pierre; Lutsep, Helmi; Nesbit, Gary; Grobelny, Thomas; Rymer, Marilyn M.; Silverman, Isaac E.; Higashida, Randall T.; Budzik, Ronald F.; Marks, Michael P.

In: Stroke, Vol. 36, No. 7, 07.2005, p. 1432-1438.

Research output: Contribution to journalArticle

Smith, WS, Sung, G, Starkman, S, Saver, JL, Kidwell, CS, Gobin, YP, Lutsep, H, Nesbit, G, Grobelny, T, Rymer, MM, Silverman, IE, Higashida, RT, Budzik, RF & Marks, MP 2005, 'Safety and efficacy of mechanical embolectomy in acute ischemic stroke: Results of the MERCI trial', Stroke, vol. 36, no. 7, pp. 1432-1438. https://doi.org/10.1161/01.STR.0000171066.25248.1d
Smith, Wade S. ; Sung, Gene ; Starkman, Sidney ; Saver, Jeffrey L. ; Kidwell, Chelsea S. ; Gobin, Y. Pierre ; Lutsep, Helmi ; Nesbit, Gary ; Grobelny, Thomas ; Rymer, Marilyn M. ; Silverman, Isaac E. ; Higashida, Randall T. ; Budzik, Ronald F. ; Marks, Michael P. / Safety and efficacy of mechanical embolectomy in acute ischemic stroke : Results of the MERCI trial. In: Stroke. 2005 ; Vol. 36, No. 7. pp. 1432-1438.
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