SAC1 lipid phosphatase and growth control of the secretory pathway

Anastasia Blagoveshchenskaya, Peter Mayinger

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

Phosphoinositide lipids play a dual role in cell physiology. Specific sets of these molecules are short-lived downstream mediators of growth signals, regulating cell survival and differentiation. In addition, distinct classes of phosphoinositide lipids function as constitutive mediators of membrane traffic and organelle identity. Recent work has provided the first direct evidence that phosphoinositides also play a direct role in linking protein secretion with cell growth and proliferation. This review focuses on SAC1 lipid phosphatase and how this enzyme operates in an evolutionary conserved mechanism to coordinate the secretory capacity of ER and Golgi during cell growth.

Original languageEnglish (US)
Pages (from-to)36-42
Number of pages7
JournalMolecular BioSystems
Volume5
Issue number1
DOIs
StatePublished - Jan 1 2009

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology

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