Royal flush: Fatal forty DDI: Methadone, nortriptyline, CYP2D6, CYP3A4

Kimberly Mauer, Catherine Marcucci, Neil B. Sandson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This case discusses a pharmacokinetic interaction between nortriptyline and methadone, resulting in tricyclic antidepressant toxicity. Nortriptyline is a cytochrome P450 (CYP) 2D6 and 3A4 substrate. Methadone is an inhibitor of those enzymes.

Original languageEnglish (US)
Title of host publicationA Case Approach to Perioperative Drug-Drug Interactions
PublisherSpringer New York
Pages253-255
Number of pages3
ISBN (Electronic)9781461474951
ISBN (Print)9781461474944
DOIs
StatePublished - Sep 15 2015

ASJC Scopus subject areas

  • Medicine(all)

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