Royal flush: Fatal forty DDI: Methadone, nortriptyline, CYP2D6, CYP3A4

Kimberly Mauer; Catherine Marcucci; Neil B. Sandson

doi:10.1007/978-1-4614-7495-1_52

Royal flush: Fatal forty DDI: Methadone, nortriptyline, CYP2D6, CYP3A4

Kimberly Mauer, Catherine Marcucci, Neil B. Sandson

Anesthesiology and Perioperative Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

This case discusses a pharmacokinetic interaction between nortriptyline and methadone, resulting in tricyclic antidepressant toxicity. Nortriptyline is a cytochrome P450 (CYP) 2D6 and 3A4 substrate. Methadone is an inhibitor of those enzymes.

Original language	English (US)
Title of host publication	A Case Approach to Perioperative Drug-Drug Interactions
Publisher	Springer New York
Pages	253-255
Number of pages	3
ISBN (Electronic)	9781461474951
ISBN (Print)	9781461474944
DOIs	https://doi.org/10.1007/978-1-4614-7495-1_52
State	Published - Sep 15 2015

ASJC Scopus subject areas

General Medicine

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10.1007/978-1-4614-7495-1_52

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abstract = "This case discusses a pharmacokinetic interaction between nortriptyline and methadone, resulting in tricyclic antidepressant toxicity. Nortriptyline is a cytochrome P450 (CYP) 2D6 and 3A4 substrate. Methadone is an inhibitor of those enzymes.",

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Royal flush: Fatal forty DDI: Methadone, nortriptyline, CYP2D6, CYP3A4

Abstract

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