Role of ventilation, air filtration, and allergen production rate in determining concentrations of rat allergens in the air of animal quarters

M. C. Swanson, A. R. Campbell, Mark O'Hollaren, C. E. Reed

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Concentration of any substance in the air of a room is determined by the ratio between the rates of its production and removal. Thus, high concentrations can result from high production, low removal, or a combination of the two. Air filtration can supplement ventilation in removing allergens from the air. Control of aeroallergen exposure at any particular location would be more rational and effective if the contribution of production, ventilation, and filtration were known. Using immunochemical assays for rat urinary protein allergen, we measured the rate of production by individual rats and the concentration of allergens in the air of rat animal quarters where the ventilation rate was about 15 changes per hour. We introduced two different high-efficiency filtration systems that provided additional clean air changes up to a maximum of 127 changes per hour. Male rats shed about 20 ng/min of allergen. Because of this high rate of production, substantial reduction in rooms that housed large numbers of animals required the very high air-exchange rates that were acheived with laminar flow small animal isolator racks. Measured concentrations agreed well with concentrations calculated from a mass balance equation whose terms included numbers of animals in the room, production rate by individual animals, and rates of ventilation and filtration. We suggest that this principle of considering both production and removal rates applies not only to devising means of reducing levels of rat allergens in rat rooms, but generally to other indoor allergens as well.

Original languageEnglish (US)
Pages (from-to)1578-1581
Number of pages4
JournalAmerican Review of Respiratory Disease
Volume141
Issue number6
StatePublished - 1990
Externally publishedYes

Fingerprint

Allergens
Ventilation
Air
Proteins

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Role of ventilation, air filtration, and allergen production rate in determining concentrations of rat allergens in the air of animal quarters. / Swanson, M. C.; Campbell, A. R.; O'Hollaren, Mark; Reed, C. E.

In: American Review of Respiratory Disease, Vol. 141, No. 6, 1990, p. 1578-1581.

Research output: Contribution to journalArticle

@article{d17a865823e8479c9752a18258b98cca,
title = "Role of ventilation, air filtration, and allergen production rate in determining concentrations of rat allergens in the air of animal quarters",
abstract = "Concentration of any substance in the air of a room is determined by the ratio between the rates of its production and removal. Thus, high concentrations can result from high production, low removal, or a combination of the two. Air filtration can supplement ventilation in removing allergens from the air. Control of aeroallergen exposure at any particular location would be more rational and effective if the contribution of production, ventilation, and filtration were known. Using immunochemical assays for rat urinary protein allergen, we measured the rate of production by individual rats and the concentration of allergens in the air of rat animal quarters where the ventilation rate was about 15 changes per hour. We introduced two different high-efficiency filtration systems that provided additional clean air changes up to a maximum of 127 changes per hour. Male rats shed about 20 ng/min of allergen. Because of this high rate of production, substantial reduction in rooms that housed large numbers of animals required the very high air-exchange rates that were acheived with laminar flow small animal isolator racks. Measured concentrations agreed well with concentrations calculated from a mass balance equation whose terms included numbers of animals in the room, production rate by individual animals, and rates of ventilation and filtration. We suggest that this principle of considering both production and removal rates applies not only to devising means of reducing levels of rat allergens in rat rooms, but generally to other indoor allergens as well.",
author = "Swanson, {M. C.} and Campbell, {A. R.} and Mark O'Hollaren and Reed, {C. E.}",
year = "1990",
language = "English (US)",
volume = "141",
pages = "1578--1581",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "American Thoracic Society",
number = "6",

}

TY - JOUR

T1 - Role of ventilation, air filtration, and allergen production rate in determining concentrations of rat allergens in the air of animal quarters

AU - Swanson, M. C.

AU - Campbell, A. R.

AU - O'Hollaren, Mark

AU - Reed, C. E.

PY - 1990

Y1 - 1990

N2 - Concentration of any substance in the air of a room is determined by the ratio between the rates of its production and removal. Thus, high concentrations can result from high production, low removal, or a combination of the two. Air filtration can supplement ventilation in removing allergens from the air. Control of aeroallergen exposure at any particular location would be more rational and effective if the contribution of production, ventilation, and filtration were known. Using immunochemical assays for rat urinary protein allergen, we measured the rate of production by individual rats and the concentration of allergens in the air of rat animal quarters where the ventilation rate was about 15 changes per hour. We introduced two different high-efficiency filtration systems that provided additional clean air changes up to a maximum of 127 changes per hour. Male rats shed about 20 ng/min of allergen. Because of this high rate of production, substantial reduction in rooms that housed large numbers of animals required the very high air-exchange rates that were acheived with laminar flow small animal isolator racks. Measured concentrations agreed well with concentrations calculated from a mass balance equation whose terms included numbers of animals in the room, production rate by individual animals, and rates of ventilation and filtration. We suggest that this principle of considering both production and removal rates applies not only to devising means of reducing levels of rat allergens in rat rooms, but generally to other indoor allergens as well.

AB - Concentration of any substance in the air of a room is determined by the ratio between the rates of its production and removal. Thus, high concentrations can result from high production, low removal, or a combination of the two. Air filtration can supplement ventilation in removing allergens from the air. Control of aeroallergen exposure at any particular location would be more rational and effective if the contribution of production, ventilation, and filtration were known. Using immunochemical assays for rat urinary protein allergen, we measured the rate of production by individual rats and the concentration of allergens in the air of rat animal quarters where the ventilation rate was about 15 changes per hour. We introduced two different high-efficiency filtration systems that provided additional clean air changes up to a maximum of 127 changes per hour. Male rats shed about 20 ng/min of allergen. Because of this high rate of production, substantial reduction in rooms that housed large numbers of animals required the very high air-exchange rates that were acheived with laminar flow small animal isolator racks. Measured concentrations agreed well with concentrations calculated from a mass balance equation whose terms included numbers of animals in the room, production rate by individual animals, and rates of ventilation and filtration. We suggest that this principle of considering both production and removal rates applies not only to devising means of reducing levels of rat allergens in rat rooms, but generally to other indoor allergens as well.

UR - http://www.scopus.com/inward/record.url?scp=0025333709&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025333709&partnerID=8YFLogxK

M3 - Article

VL - 141

SP - 1578

EP - 1581

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 6

ER -