Role of the reticuloendothelial system in the anaemia of rheumatoid arthritis. A study using the 59Fe labelled dextran model

Robert (Rob) Bennett, P. J L Holt, S. M. Lewis

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The reticuloendothelial handling of iron in rheumatoid arthritis was studied using 59Fe labelled dextran. Rheumatoid patients with anemia of chronic inflammation showed excessive uptake of iron into the liver with little subsequent mobilization. One rheumatoid patient, who was also iron deficient, was able to mobilize his hepatic iron stores normally. The ability to incorporate into circulating erythrocytes iron which has been stored in the reticuloendothelial system, was closely correlated with its subsequent mobilization from the liver.

Original languageEnglish (US)
Pages (from-to)147-152
Number of pages6
JournalAnnals of the Rheumatic Diseases
Volume33
Issue number2
StatePublished - 1974
Externally publishedYes

Fingerprint

Mononuclear Phagocyte System
Dextrans
Anemia
Rheumatoid Arthritis
Iron
Liver
Erythrocytes
Inflammation

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Role of the reticuloendothelial system in the anaemia of rheumatoid arthritis. A study using the 59Fe labelled dextran model. / Bennett, Robert (Rob); Holt, P. J L; Lewis, S. M.

In: Annals of the Rheumatic Diseases, Vol. 33, No. 2, 1974, p. 147-152.

Research output: Contribution to journalArticle

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