Role of the pituitary and the adrenals in mediating the effects of alcohol on testicular steroidogenesis in mice

Fouad M. Badr; M. Susan Smith; Susan L. Dalterio; Andrzej Bartke

doi:10.1016/0039-128X(79)90108-9

Role of the pituitary and the adrenals in mediating the effects of alcohol on testicular steroidogenesis in mice

Fouad M. Badr, M. Susan Smith, Susan L. Dalterio, Andrzej Bartke

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We have previously demonstrated that intragastric administration of alcohol (1.24 g/kg body wt) to adult male mice results in suppression of testosterone production. We now report that the decline in peripheral testosterone levels in alcohol-treated mice is not accompanied by changes in plasma levels of luteinizing hormone, follicle stimulating hormone or estradiol-17β, and that it is markedly attenuated in adrenalectomized or adrenalectomized-corticosterone treated males.

Original language	English (US)
Pages (from-to)	477-482
Number of pages	6
Journal	Steroids
Volume	34
Issue number	4
DOIs	https://doi.org/10.1016/0039-128X(79)90108-9
State	Published - Oct 1979
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Endocrinology
Pharmacology
Clinical Biochemistry
Organic Chemistry

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title = "Role of the pituitary and the adrenals in mediating the effects of alcohol on testicular steroidogenesis in mice",

abstract = "We have previously demonstrated that intragastric administration of alcohol (1.24 g/kg body wt) to adult male mice results in suppression of testosterone production. We now report that the decline in peripheral testosterone levels in alcohol-treated mice is not accompanied by changes in plasma levels of luteinizing hormone, follicle stimulating hormone or estradiol-17β, and that it is markedly attenuated in adrenalectomized or adrenalectomized-corticosterone treated males.",

author = "Badr, {Fouad M.} and Smith, {M. Susan} and Dalterio, {Susan L.} and Andrzej Bartke",

note = "Funding Information: This work was supported by NIH through grant HD-09584 (A.B.). We thank Ms. Carol Roberson for determinations of LH and FSH, NIAMDD for rat LH and FSH radioimmunoassay kits, Dr. B.V. Caldwell for antiserum to testosterone and Dr. D.C. Collins for antiserum to estradiol-178.",

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T1 - Role of the pituitary and the adrenals in mediating the effects of alcohol on testicular steroidogenesis in mice

AU - Badr, Fouad M.

AU - Smith, M. Susan

AU - Dalterio, Susan L.

AU - Bartke, Andrzej

N1 - Funding Information: This work was supported by NIH through grant HD-09584 (A.B.). We thank Ms. Carol Roberson for determinations of LH and FSH, NIAMDD for rat LH and FSH radioimmunoassay kits, Dr. B.V. Caldwell for antiserum to testosterone and Dr. D.C. Collins for antiserum to estradiol-178.

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N2 - We have previously demonstrated that intragastric administration of alcohol (1.24 g/kg body wt) to adult male mice results in suppression of testosterone production. We now report that the decline in peripheral testosterone levels in alcohol-treated mice is not accompanied by changes in plasma levels of luteinizing hormone, follicle stimulating hormone or estradiol-17β, and that it is markedly attenuated in adrenalectomized or adrenalectomized-corticosterone treated males.

AB - We have previously demonstrated that intragastric administration of alcohol (1.24 g/kg body wt) to adult male mice results in suppression of testosterone production. We now report that the decline in peripheral testosterone levels in alcohol-treated mice is not accompanied by changes in plasma levels of luteinizing hormone, follicle stimulating hormone or estradiol-17β, and that it is markedly attenuated in adrenalectomized or adrenalectomized-corticosterone treated males.

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Role of the pituitary and the adrenals in mediating the effects of alcohol on testicular steroidogenesis in mice

Abstract

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