Role of the microvascular endothelium in progressive renal disease

Duk Hee Kang, John Kanellis, Christian Hugo, Luan Truong, Sharon Anderson, Dontscho Kerjaschki, George F. Schreiner, Richard J. Johnson

Research output: Contribution to journalArticle

386 Citations (Scopus)

Abstract

The role of the vascular endothelium in progressive renal disease is not well understood. This review presents evidence that progressive renal disease is characterized by a progressive loss of the microvasculature. The loss of the microvasculature correlates directly with the development of glomerular and tubulointerstitial scarring. The mechanism is mediated in part by a reduction in the endothelial proliferative response, and this impairment in capillary repair is mediated by alteration in the local expression of both angiogenic (vascular endothelial growth factor) and antiangiogenic (thrombospondin 1) factors in the kidney. The alteration in balance of angiogenic growth factors is mediated by both macrophage-associated cytokines (interleukin-1β) and vasoactive mediators. Finally, there is intriguing evidence that stimulation of angiogenesis and/or capillary repair may stabilize renal function and slow progression and that this benefit occurs independently of effects on BP or proteinuria. Therefore, angiogenic agents may represent a novel therapeutic approach for slowing the progression of renal disease.

Original languageEnglish (US)
Pages (from-to)806-816
Number of pages11
JournalJournal of the American Society of Nephrology
Volume13
Issue number3
StatePublished - 2002
Externally publishedYes

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Endothelium
Kidney
Microvessels
Thrombospondin 1
Angiogenesis Inducing Agents
Vascular Endothelium
Interleukin-1
Proteinuria
Vascular Endothelial Growth Factor A
Cicatrix
Disease Progression
Intercellular Signaling Peptides and Proteins
Macrophages
Cytokines
Therapeutics

ASJC Scopus subject areas

  • Nephrology

Cite this

Kang, D. H., Kanellis, J., Hugo, C., Truong, L., Anderson, S., Kerjaschki, D., ... Johnson, R. J. (2002). Role of the microvascular endothelium in progressive renal disease. Journal of the American Society of Nephrology, 13(3), 806-816.

Role of the microvascular endothelium in progressive renal disease. / Kang, Duk Hee; Kanellis, John; Hugo, Christian; Truong, Luan; Anderson, Sharon; Kerjaschki, Dontscho; Schreiner, George F.; Johnson, Richard J.

In: Journal of the American Society of Nephrology, Vol. 13, No. 3, 2002, p. 806-816.

Research output: Contribution to journalArticle

Kang, DH, Kanellis, J, Hugo, C, Truong, L, Anderson, S, Kerjaschki, D, Schreiner, GF & Johnson, RJ 2002, 'Role of the microvascular endothelium in progressive renal disease', Journal of the American Society of Nephrology, vol. 13, no. 3, pp. 806-816.
Kang DH, Kanellis J, Hugo C, Truong L, Anderson S, Kerjaschki D et al. Role of the microvascular endothelium in progressive renal disease. Journal of the American Society of Nephrology. 2002;13(3):806-816.
Kang, Duk Hee ; Kanellis, John ; Hugo, Christian ; Truong, Luan ; Anderson, Sharon ; Kerjaschki, Dontscho ; Schreiner, George F. ; Johnson, Richard J. / Role of the microvascular endothelium in progressive renal disease. In: Journal of the American Society of Nephrology. 2002 ; Vol. 13, No. 3. pp. 806-816.
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