Abstract
Although a critical role of adaptive immune system has been confirmed in driving local and systemic inflammation in type 2 diabetes and promoting insulin resistance, the underlying mechanism is not completely understood. Inflammatory regulation has been focused on innate immunity especially macrophage for a long time, while increasing evidence suggests T cells are crucial for the development of metabolic inflammation and insulin resistance since 2009. There was growing evidence supporting the critical implication of T cells in the pathogenesis of type 2 diabetes. We will discuss the available effect of T cells subsets in adaptive immune system associated with the procession of T2DM, which may unveil several potential strategies that could provide successful therapies in the future.
Original language | English (US) |
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Article number | 6494795 |
Journal | Journal of Diabetes Research |
Volume | 2017 |
DOIs | |
State | Published - 2017 |
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology