Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation

Chang Xia, Xiaoquan Rao, Jixin Zhong

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

Although a critical role of adaptive immune system has been confirmed in driving local and systemic inflammation in type 2 diabetes and promoting insulin resistance, the underlying mechanism is not completely understood. Inflammatory regulation has been focused on innate immunity especially macrophage for a long time, while increasing evidence suggests T cells are crucial for the development of metabolic inflammation and insulin resistance since 2009. There was growing evidence supporting the critical implication of T cells in the pathogenesis of type 2 diabetes. We will discuss the available effect of T cells subsets in adaptive immune system associated with the procession of T2DM, which may unveil several potential strategies that could provide successful therapies in the future.

Original languageEnglish (US)
Article number6494795
JournalJournal of Diabetes Research
Volume2017
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Fingerprint

Type 2 Diabetes Mellitus
Insulin Resistance
Immune System
Inflammation
T-Lymphocytes
T-Lymphocyte Subsets
Innate Immunity
Macrophages
Therapeutics

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation. / Xia, Chang; Rao, Xiaoquan; Zhong, Jixin.

In: Journal of Diabetes Research, Vol. 2017, 6494795, 01.01.2017.

Research output: Contribution to journalReview article

@article{aaf1b669230c4a35b2134b32ff6ee848,
title = "Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation",
abstract = "Although a critical role of adaptive immune system has been confirmed in driving local and systemic inflammation in type 2 diabetes and promoting insulin resistance, the underlying mechanism is not completely understood. Inflammatory regulation has been focused on innate immunity especially macrophage for a long time, while increasing evidence suggests T cells are crucial for the development of metabolic inflammation and insulin resistance since 2009. There was growing evidence supporting the critical implication of T cells in the pathogenesis of type 2 diabetes. We will discuss the available effect of T cells subsets in adaptive immune system associated with the procession of T2DM, which may unveil several potential strategies that could provide successful therapies in the future.",
author = "Chang Xia and Xiaoquan Rao and Jixin Zhong",
year = "2017",
month = "1",
day = "1",
doi = "10.1155/2017/6494795",
language = "English (US)",
volume = "2017",
journal = "Journal of Diabetes Research",
issn = "2314-6745",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation

AU - Xia, Chang

AU - Rao, Xiaoquan

AU - Zhong, Jixin

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Although a critical role of adaptive immune system has been confirmed in driving local and systemic inflammation in type 2 diabetes and promoting insulin resistance, the underlying mechanism is not completely understood. Inflammatory regulation has been focused on innate immunity especially macrophage for a long time, while increasing evidence suggests T cells are crucial for the development of metabolic inflammation and insulin resistance since 2009. There was growing evidence supporting the critical implication of T cells in the pathogenesis of type 2 diabetes. We will discuss the available effect of T cells subsets in adaptive immune system associated with the procession of T2DM, which may unveil several potential strategies that could provide successful therapies in the future.

AB - Although a critical role of adaptive immune system has been confirmed in driving local and systemic inflammation in type 2 diabetes and promoting insulin resistance, the underlying mechanism is not completely understood. Inflammatory regulation has been focused on innate immunity especially macrophage for a long time, while increasing evidence suggests T cells are crucial for the development of metabolic inflammation and insulin resistance since 2009. There was growing evidence supporting the critical implication of T cells in the pathogenesis of type 2 diabetes. We will discuss the available effect of T cells subsets in adaptive immune system associated with the procession of T2DM, which may unveil several potential strategies that could provide successful therapies in the future.

UR - http://www.scopus.com/inward/record.url?scp=85013344047&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85013344047&partnerID=8YFLogxK

U2 - 10.1155/2017/6494795

DO - 10.1155/2017/6494795

M3 - Review article

VL - 2017

JO - Journal of Diabetes Research

JF - Journal of Diabetes Research

SN - 2314-6745

M1 - 6494795

ER -