Role of surgery in limited (T1-2, N0-1) cancers of the oropharynx

Rohan R. Walvekar, Ryan Li, William E. Gooding, Michael K. Gibson, Dwight Heron, Jonas T. Johnson, Robert L. Ferris

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Hypothesis: To define the role of surgical staging in limited (T1-2, N0-1) oropharyngeal squamous cell cancers. Study Design: Retrospective. Methods: Forty-nine limited oropharyngeal squamous cell cancers of the tonsil, tongue base, or posterior pharyngeal wall-treated surgically were identified. Results: Thirty-five percent were cT1 and 65% were cT2 tumors although 58% were cNO and 42% were cN1. Forty-six patients underwent neck dissections. Surgical staging altered T-stage in 26% (13/49), nodal status in 23% (11/46), and clinical staging in 40% (20/49) of patients. Among 35 disease-free patients, 28% (4/20) of stage I/II patients received postoperative radiation and chemotherapy was avoided in 80% (12/15) of stage III patients. II tumors seemed to have better outcomes (P=.06). The 3 year disease-free survival and 5 year overall survival was 85% and 83%, respectively. Conclusions: Surgical staging identifies patients in whom intensification of treatment with chemotherapy can be most appropriately applied, and enables deintensification of therapy in pathology confirmed stage I/II disease.

Original languageEnglish (US)
Pages (from-to)2129-2134
Number of pages6
JournalLaryngoscope
Volume118
Issue number12
DOIs
StatePublished - Dec 2008
Externally publishedYes

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Oropharyngeal Neoplasms
Squamous Cell Neoplasms
Tonsillar Neoplasms
Tongue Neoplasms
Drug Therapy
Neck Dissection
Disease-Free Survival
Neoplasms
Retrospective Studies
Radiation
Pathology
Survival
Therapeutics

Keywords

  • Early
  • Limited
  • Oropharyngeal cancer
  • Squamous cell carcinoma
  • Surgical therapy

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Walvekar, R. R., Li, R., Gooding, W. E., Gibson, M. K., Heron, D., Johnson, J. T., & Ferris, R. L. (2008). Role of surgery in limited (T1-2, N0-1) cancers of the oropharynx. Laryngoscope, 118(12), 2129-2134. https://doi.org/10.1097/MLG.0b013e3181857950

Role of surgery in limited (T1-2, N0-1) cancers of the oropharynx. / Walvekar, Rohan R.; Li, Ryan; Gooding, William E.; Gibson, Michael K.; Heron, Dwight; Johnson, Jonas T.; Ferris, Robert L.

In: Laryngoscope, Vol. 118, No. 12, 12.2008, p. 2129-2134.

Research output: Contribution to journalArticle

Walvekar, RR, Li, R, Gooding, WE, Gibson, MK, Heron, D, Johnson, JT & Ferris, RL 2008, 'Role of surgery in limited (T1-2, N0-1) cancers of the oropharynx', Laryngoscope, vol. 118, no. 12, pp. 2129-2134. https://doi.org/10.1097/MLG.0b013e3181857950
Walvekar RR, Li R, Gooding WE, Gibson MK, Heron D, Johnson JT et al. Role of surgery in limited (T1-2, N0-1) cancers of the oropharynx. Laryngoscope. 2008 Dec;118(12):2129-2134. https://doi.org/10.1097/MLG.0b013e3181857950
Walvekar, Rohan R. ; Li, Ryan ; Gooding, William E. ; Gibson, Michael K. ; Heron, Dwight ; Johnson, Jonas T. ; Ferris, Robert L. / Role of surgery in limited (T1-2, N0-1) cancers of the oropharynx. In: Laryngoscope. 2008 ; Vol. 118, No. 12. pp. 2129-2134.
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