Role of stearoyl-CoA desaturase in human metabolic disease

Harini Sampath, James M. Ntambi

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Stearoyl-CoA desaturase (SCD) is a highly conserved Δ-9 desaturase that converts saturated fatty acids into monounsaturated fatty acids. Mice lacking the Scd1 gene are characterized by decreased adiposity and increased lipid oxidation and insulin sensitivity in liver and skeletal muscle. Two isoforms of SCD have also been identified in humans, and there appears to be an association between SCD expression and adiposity. This review will provide a brief update of recent progress in understanding the role of SCD in mediating the progression of disease in human populations, with a special emphasis on metabolic disease.

Original languageEnglish (US)
Pages (from-to)163-173
Number of pages11
JournalFuture Lipidology
Volume3
Issue number2
DOIs
StatePublished - Apr 1 2008

Keywords

  • Desaturation ratio
  • Hypertriglyceridemia
  • Insulin sensitivity
  • Lipid oxidation
  • Lipogenesis
  • Metabolic syndrome
  • Stearoyl CoA desaturase

ASJC Scopus subject areas

  • Biochemistry

Fingerprint Dive into the research topics of 'Role of stearoyl-CoA desaturase in human metabolic disease'. Together they form a unique fingerprint.

  • Cite this