Role of serotonin transporter promoter repeat length polymorphism (5-HTTLPR) in seasonality and seasonal affective disorder

N. E. Rosenthal, C. M. Mazzanti, R. L. Barnett, T. A. Hardin, Erick Turner, G. K. Lam, N. Ozaki, D. Goldman

Research output: Contribution to journalArticle

146 Citations (Scopus)

Abstract

Seasonal variations in mood and behavior (seasonality) and seasonal affective disorder (SAD) have been attributed to seasonal fluctuations in brain serotonin (5-HT). The short (s), as opposed to the long (l), allele of the 5-HT transporter linked polymorphism (5-HTTLPR) has been associated with neuroticism and depression. We hypothesized that this short allele would also be associated with SAD and with higher levels of seasonality. Ninety-seven SAD patients and 71 non-seasonal healthy controls with low seasonality levels were genotyped for 5-HTTLPR and compared statistically. Patients with SAD were less likely to have the l/l genotype (27.8% vs 47.9%; P < 0.01) and more likely to have the s allele (44.8% vs 32.4%; P < 0.02) as compared to controls. The three 5-HTTLPR genotypes were also differentially distributed in patients and controls (P < 0.03). The SAD patients with the l/l genotype had a lower mean seasonality score than did patients with the other two genotypes (mean ± s.d., = 15.3 ± 2.8 vs 17.1 ± 3.4 respectively; P < 0.02). The 5-HTTLPR short allele contributes to the trait of seasonality and is a risk factor for SAD, providing further evidence for a relationship between genetic variation in the 5-HT transporter (5-HTT) and behavior.

Original languageEnglish (US)
Pages (from-to)175-177
Number of pages3
JournalMolecular Psychiatry
Volume3
Issue number2
StatePublished - 1998
Externally publishedYes

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Seasonal Affective Disorder
Serotonin Plasma Membrane Transport Proteins
Serotonin
Alleles
Genotype
Depression
Brain

Keywords

  • Seasonal affective disorder
  • Seasonality
  • Serotonin transporter gene

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health

Cite this

Rosenthal, N. E., Mazzanti, C. M., Barnett, R. L., Hardin, T. A., Turner, E., Lam, G. K., ... Goldman, D. (1998). Role of serotonin transporter promoter repeat length polymorphism (5-HTTLPR) in seasonality and seasonal affective disorder. Molecular Psychiatry, 3(2), 175-177.

Role of serotonin transporter promoter repeat length polymorphism (5-HTTLPR) in seasonality and seasonal affective disorder. / Rosenthal, N. E.; Mazzanti, C. M.; Barnett, R. L.; Hardin, T. A.; Turner, Erick; Lam, G. K.; Ozaki, N.; Goldman, D.

In: Molecular Psychiatry, Vol. 3, No. 2, 1998, p. 175-177.

Research output: Contribution to journalArticle

Rosenthal, NE, Mazzanti, CM, Barnett, RL, Hardin, TA, Turner, E, Lam, GK, Ozaki, N & Goldman, D 1998, 'Role of serotonin transporter promoter repeat length polymorphism (5-HTTLPR) in seasonality and seasonal affective disorder', Molecular Psychiatry, vol. 3, no. 2, pp. 175-177.
Rosenthal, N. E. ; Mazzanti, C. M. ; Barnett, R. L. ; Hardin, T. A. ; Turner, Erick ; Lam, G. K. ; Ozaki, N. ; Goldman, D. / Role of serotonin transporter promoter repeat length polymorphism (5-HTTLPR) in seasonality and seasonal affective disorder. In: Molecular Psychiatry. 1998 ; Vol. 3, No. 2. pp. 175-177.
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