Role of serotonergic input in the regulation of the β-adrenergic receptor-coupled adenylate cyclase system

Aaron Janowsky, Fumihiko Okada, D. Hal Manier, Craig D. Applegate, Fridolin Sulser, Larry R. Steranka

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

The action of desipramine on the norepinephrine-sensitive adenylate cyclase system and the density of β-adrenergic receptors in rat cortex was studied after selective lesioning of serotonergic neurons with 5,7-dihydroxytryptamine. In animals with lesions desipramine failed to reduce the density of β-adrenoceptors but decreased the response of adenosine 3′,5′-monophosphate to isoproterenol and norepinephrine to the same degree as in animals without lesions. The results demonstrate a functional linkage between serotonergic and noradrenergic systems in the rat cortex, with β-adrenergic receptors and neurohormonal sensitivity of the adenosine 3′,5′-monophosphate-generating system being under separate regulatory control.

Original languageEnglish (US)
Pages (from-to)898-899
Number of pages2
JournalScience
Volume218
Issue number4575
StatePublished - 1982
Externally publishedYes

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Adenylyl Cyclases
Adrenergic Receptors
Desipramine
Adenosine
Norepinephrine
5,7-Dihydroxytryptamine
Serotonergic Neurons
Isoproterenol

ASJC Scopus subject areas

  • General

Cite this

Janowsky, A., Okada, F., Manier, D. H., Applegate, C. D., Sulser, F., & Steranka, L. R. (1982). Role of serotonergic input in the regulation of the β-adrenergic receptor-coupled adenylate cyclase system. Science, 218(4575), 898-899.

Role of serotonergic input in the regulation of the β-adrenergic receptor-coupled adenylate cyclase system. / Janowsky, Aaron; Okada, Fumihiko; Manier, D. Hal; Applegate, Craig D.; Sulser, Fridolin; Steranka, Larry R.

In: Science, Vol. 218, No. 4575, 1982, p. 898-899.

Research output: Contribution to journalArticle

Janowsky, A, Okada, F, Manier, DH, Applegate, CD, Sulser, F & Steranka, LR 1982, 'Role of serotonergic input in the regulation of the β-adrenergic receptor-coupled adenylate cyclase system', Science, vol. 218, no. 4575, pp. 898-899.
Janowsky A, Okada F, Manier DH, Applegate CD, Sulser F, Steranka LR. Role of serotonergic input in the regulation of the β-adrenergic receptor-coupled adenylate cyclase system. Science. 1982;218(4575):898-899.
Janowsky, Aaron ; Okada, Fumihiko ; Manier, D. Hal ; Applegate, Craig D. ; Sulser, Fridolin ; Steranka, Larry R. / Role of serotonergic input in the regulation of the β-adrenergic receptor-coupled adenylate cyclase system. In: Science. 1982 ; Vol. 218, No. 4575. pp. 898-899.
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