The action of desipramine on the norepinephrine-sensitive adenylate cyclase system and the density of β-adrenergic receptors in rat cortex was studied after selective lesioning of serotonergic neurons with 5,7-dihydroxytryptamine. In animals with lesions desipramine failed to reduce the density of β-adrenoceptors but decreased the response of adenosine 3′,5′-monophosphate to isoproterenol and norepinephrine to the same degree as in animals without lesions. The results demonstrate a functional linkage between serotonergic and noradrenergic systems in the rat cortex, with β-adrenergic receptors and neurohormonal sensitivity of the adenosine 3′,5′-monophosphate-generating system being under separate regulatory control.
|Original language||English (US)|
|Number of pages||2|
|State||Published - Jan 1 1982|
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