Role of serotonergic input in the regulation of the β-adrenergic receptor-coupled adenylate cyclase system

Aaron Janowsky, F. Okada, D. H. Manier, C. D. Applegate, F. Sulser, L. R. Steranka

Research output: Contribution to journalArticle

Abstract

The action of desipramine on the norphinephrine-sensitive adenylate cyclase system and the density of β-adrenergic receptors in rat cortex was studied after selective lesioning of serotonergic neurons with 5.7-dihydroxytryptamine. In animals with lesions desipramine failed to reduce the density of β-adrenoreceptors but decreased the response of adenosine 3',5'-monophosphate to isoproterenol and norephinephrine to the same degree as in animals with lesions. The results demonstrate a functional linkage between serotonergic and noradrenergic systems in the rat cortex, with β-adrenergic receptor and neurohormonal sensitivity of the adenosine 3',5'-monophosphate-generating system being under separate regulatory control.

Original languageEnglish (US)
Pages (from-to)900-901
Number of pages2
JournalScience
Volume218
Issue number4575
DOIs
StatePublished - 1982
Externally publishedYes

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Desipramine
Adenylyl Cyclases
Dihydroxytryptamines
Adenosine
Adrenergic Receptors
Serotonergic Neurons
Isoproterenol

ASJC Scopus subject areas

  • General

Cite this

Role of serotonergic input in the regulation of the β-adrenergic receptor-coupled adenylate cyclase system. / Janowsky, Aaron; Okada, F.; Manier, D. H.; Applegate, C. D.; Sulser, F.; Steranka, L. R.

In: Science, Vol. 218, No. 4575, 1982, p. 900-901.

Research output: Contribution to journalArticle

Janowsky, Aaron ; Okada, F. ; Manier, D. H. ; Applegate, C. D. ; Sulser, F. ; Steranka, L. R. / Role of serotonergic input in the regulation of the β-adrenergic receptor-coupled adenylate cyclase system. In: Science. 1982 ; Vol. 218, No. 4575. pp. 900-901.
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