Role of serotonergic input in the regulation of the β-adrenergic receptor-coupled adenylate cyclase system

Aaron Janowsky, Fumihiko Okada, D. Hal Manier, Craig D. Applegate, Fridolin Sulser, Larry R. Steranka

Research output: Contribution to journalArticle

134 Scopus citations

Abstract

The action of desipramine on the norepinephrine-sensitive adenylate cyclase system and the density of β-adrenergic receptors in rat cortex was studied after selective lesioning of serotonergic neurons with 5,7-dihydroxytryptamine. In animals with lesions desipramine failed to reduce the density of β-adrenoceptors but decreased the response of adenosine 3′,5′-monophosphate to isoproterenol and norepinephrine to the same degree as in animals without lesions. The results demonstrate a functional linkage between serotonergic and noradrenergic systems in the rat cortex, with β-adrenergic receptors and neurohormonal sensitivity of the adenosine 3′,5′-monophosphate-generating system being under separate regulatory control.

Original languageEnglish (US)
Pages (from-to)898-899
Number of pages2
JournalScience
Volume218
Issue number4575
StatePublished - Jan 1 1982

ASJC Scopus subject areas

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    Janowsky, A., Okada, F., Manier, D. H., Applegate, C. D., Sulser, F., & Steranka, L. R. (1982). Role of serotonergic input in the regulation of the β-adrenergic receptor-coupled adenylate cyclase system. Science, 218(4575), 898-899.