Role of proteoglycans in the trabecular meshwork

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The primary risk factor for glaucoma is elevated intraocular pressure, which results from an unidentified increase in the resistance to aqueous humor outflow through the trabecular meshwork. Glycosaminoglycans are likely contributors to the normal and glaucomatous outflow resistance. Proteoglycans (PGs), with their highly charged glycosaminoglycan side chains, are critical components of the structure and organization of the outflow resistance within the trabecular meshwork. The members of most families of PGs have been identified in the outflow pathway and their turnover and biosynthetic replacement appear to be a key component of the homeostatic mechanism of intraocular pressure regulation.

Original languageEnglish (US)
Title of host publicationThe Curated Reference Collection in Neuroscience and Biobehavioral Psychology
PublisherElsevier Science Ltd.
Pages170-178
Number of pages9
ISBN (Electronic)9780128093245
DOIs
StatePublished - Jan 1 2016

Keywords

  • Aqueous humor outflow resistance
  • Biglycan
  • CD44
  • Decorin
  • Extracellular matrix
  • Fibromodulin
  • Glycosaminoglycan
  • Glypican
  • Hyaluronan
  • Perlecan
  • Proteoglycan
  • Syndecan
  • Testican
  • Trabecular meshwork
  • Versican

ASJC Scopus subject areas

  • Medicine(all)

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