Role of proteoglycans in the trabecular meshwork

T. S. Acott; K. E. Keller; M. J. Kelley

doi:10.1016/B978-0-12-809324-5.01518-2

Role of proteoglycans in the trabecular meshwork

T. S. Acott, K. E. Keller, M. J. Kelley

Ophthalmology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The primary risk factor for glaucoma is elevated intraocular pressure, which results from an unidentified increase in the resistance to aqueous humor outflow through the trabecular meshwork. Glycosaminoglycans are likely contributors to the normal and glaucomatous outflow resistance. Proteoglycans (PGs), with their highly charged glycosaminoglycan side chains, are critical components of the structure and organization of the outflow resistance within the trabecular meshwork. The members of most families of PGs have been identified in the outflow pathway and their turnover and biosynthetic replacement appear to be a key component of the homeostatic mechanism of intraocular pressure regulation.

Original language	English (US)
Title of host publication	The Curated Reference Collection in Neuroscience and Biobehavioral Psychology
Publisher	Elsevier Science Ltd.
Pages	170-178
Number of pages	9
ISBN (Electronic)	9780128093245
DOIs	https://doi.org/10.1016/B978-0-12-809324-5.01518-2
State	Published - Jan 1 2016

Keywords

Aqueous humor outflow resistance
Biglycan
CD44
Decorin
Extracellular matrix
Fibromodulin
Glycosaminoglycan
Glypican
Hyaluronan
Perlecan
Proteoglycan
Syndecan
Testican
Trabecular meshwork
Versican

ASJC Scopus subject areas

General Medicine

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10.1016/B978-0-12-809324-5.01518-2

Cite this

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title = "Role of proteoglycans in the trabecular meshwork",

abstract = "The primary risk factor for glaucoma is elevated intraocular pressure, which results from an unidentified increase in the resistance to aqueous humor outflow through the trabecular meshwork. Glycosaminoglycans are likely contributors to the normal and glaucomatous outflow resistance. Proteoglycans (PGs), with their highly charged glycosaminoglycan side chains, are critical components of the structure and organization of the outflow resistance within the trabecular meshwork. The members of most families of PGs have been identified in the outflow pathway and their turnover and biosynthetic replacement appear to be a key component of the homeostatic mechanism of intraocular pressure regulation.",

keywords = "Aqueous humor outflow resistance, Biglycan, CD44, Decorin, Extracellular matrix, Fibromodulin, Glycosaminoglycan, Glypican, Hyaluronan, Perlecan, Proteoglycan, Syndecan, Testican, Trabecular meshwork, Versican",

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AU - Kelley, M. J.

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N2 - The primary risk factor for glaucoma is elevated intraocular pressure, which results from an unidentified increase in the resistance to aqueous humor outflow through the trabecular meshwork. Glycosaminoglycans are likely contributors to the normal and glaucomatous outflow resistance. Proteoglycans (PGs), with their highly charged glycosaminoglycan side chains, are critical components of the structure and organization of the outflow resistance within the trabecular meshwork. The members of most families of PGs have been identified in the outflow pathway and their turnover and biosynthetic replacement appear to be a key component of the homeostatic mechanism of intraocular pressure regulation.

AB - The primary risk factor for glaucoma is elevated intraocular pressure, which results from an unidentified increase in the resistance to aqueous humor outflow through the trabecular meshwork. Glycosaminoglycans are likely contributors to the normal and glaucomatous outflow resistance. Proteoglycans (PGs), with their highly charged glycosaminoglycan side chains, are critical components of the structure and organization of the outflow resistance within the trabecular meshwork. The members of most families of PGs have been identified in the outflow pathway and their turnover and biosynthetic replacement appear to be a key component of the homeostatic mechanism of intraocular pressure regulation.

KW - Aqueous humor outflow resistance

KW - Biglycan

KW - CD44

KW - Decorin

KW - Extracellular matrix

KW - Fibromodulin

KW - Glycosaminoglycan

KW - Glypican

KW - Hyaluronan

KW - Perlecan

KW - Proteoglycan

KW - Syndecan

KW - Testican

KW - Trabecular meshwork

KW - Versican

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BT - The Curated Reference Collection in Neuroscience and Biobehavioral Psychology

PB - Elsevier Science Ltd.

ER -

Role of proteoglycans in the trabecular meshwork

Abstract

Keywords

ASJC Scopus subject areas

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